Life Science Research

For over forty years Digitimer have designed, manufactured and distributed a wide range of quality electrophysiology equipment, including biological amplifiers, stimulators and other products, used by biomedical researchers worldwide. We offer a variety of in vitro and in vivo electrophysiology equipment to complement our own products and currently represent eight respected life science research instrument manufacturers. Please use the drop-down menu above or the product/category links below to discover more about the equipment you may be interested in.

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  • Acquisition Interfaces

    We offer a range of data acquisition (DAQ) interfaces including some from National Instruments, which are vital components within QtracW-based threshold-tracking nerve, muscle and cortical excitability systems.

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  • Amplifiers

    As leaders in our field, we manufacture and supply a wide range of biological amplifiers. These are designed for use in biomedical research and clinical environments. Our research amplifiers are suitable for intracellular/extracellular recording, multi-channel recording and transducer monitoring. We also have a range of isolated amplifiers, some medically approved, for human EMG, EEG and EP recording.
    These are all high-specification, quality devices – yet they’re still available for a competitive price. Whatever the nature of your latest research study, we’re confident we have the ideal amplifier to meet your needs. So, why not take a look through our full collection? Further information on each device can be found in our product brochure. But if you have any questions, or need help choosing the ideal amplifier, please don’t hesitate to get in touch. [vc_tta_accordion active_section="0" collapsible_all="true"][vc_tta_section title="Why shop with us for amplifiers?" tab_id="1645615373920-f10d4f90-d20e"][vc_column_text]Digitimer is a leading designer and manufacturer of scientific devices, particularly for use in biomedical research. In fact, our amplifiers are now used in studies all over the world.

    Since our establishment, we’ve honed our skills in this area and developed a series of cutting-edge biological and isolated amplifiers, which fully meet the needs of specific users. Nevertheless, we still like to push ourselves. Working in collaboration with universities and hospitals, we’re committed to product development and continuously strive to create new, innovative products for our clients.

    One of our latest developments includes the D360R multi-channel isolated research amplifier. This is based on our 8-channel D360 isolated patient amplifier, but is the 4-channel research equivalent: compact, cost-effective, yet highly specified and designed for use in EMG, EEG and EP recording.

    All products in our amplifier range are CE certified. They’re available for a very competitive price and, as a team of specialists, we like to offer our clients an excellent pre- and post-sales service.[/vc_column_text][/vc_tta_section][vc_tta_section title="Which is the right amplifier for my research?" tab_id="1645615373927-6ff4f2e6-993e"][vc_column_text]Whilst many of our amplifiers are designed to be ‘general purpose’, each one has features that make it more suitable for a particular type of recording – and it’s worth taking this into consideration when placing your order.

    Detailed information can be found under each product listing and in our product brochure. Our NeuroLog System amplifier modules and SPP-100 Extracellular Amplifier are intended for a range of in vitro and animal research applications. For our amplifiers intended for human use, we have a blog that focuses specifically on how to select an appropriate isolated amplifier.

    These resources should help you to narrow down the options and identify the most appropriate device. But if you’re still unsure, please feel free to give us a call. Once we know a bit more about the intended application and requirements of your research, our in-house experts can guide you through the selection process and advise on the most suitable amplifier for your needs.[/vc_column_text][/vc_tta_section][vc_tta_section title="How much do amplifiers cost?" tab_id="1645615507131-9c13d892-be2c"][vc_column_text]This varies depending on the type of amplifier that you require.

    The manufacturer’s Net List Price for each device is displayed below. But it’s important to be aware, this excludes UK VAT and shipping costs. And if you live outside of the UK, the price you pay for a particular amplifier will depend on how Digitimer Ltd is represented and supported in your country.

    In most cases, the best option is to submit a request for a quote. Just add the amplifier to your ‘quote list’ and provide a few details, including how you intend to use it. We’ll respond as soon as possible with application-specific advice and a tailored quote for your needs.

    Alternatively, you’re welcome to call us at any time. We’re always happy to help and will gladly talk you through the biological and isolated amplifiers available and their associated costs.[/vc_column_text][/vc_tta_section][/vc_tta_accordion]

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  • Anti Vibration Equipment

    Techniques involving manipulation under microscopic control are vibration sensitive, therefore, it is necessary to invest in a good anti-vibration table as the first stage when assembling a new electrophysiology rig.

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  • Cell Injectors

    Our range of cell injectors includes the PLI-10A and PLI-100A Pico-injectors from Warner Instruments, the electric IM-400, pneumatic IM-11-2 and syringe-based IMS-20 injectors from Narishige.

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  • Incubators & Chambers

    With products from Scientific Systems Design (SSD) and AutoMate Scientific, we supply a vast array of free-standing chambers for slices in interface and submerged recording modes as well as stage mounted versions for slice and cell culture preparations under ambient and temperature-controlled conditions.  We also provide brain slice keepers for pre-incubation of brain and other tissue slices prior to electrophysiological recording or imaging.

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  • Iontophoretic Devices

    Digitimer manufactures the D380 Iontophoretic Dye Marker, useful for neuroanatomical dye labelling when a current injecting amplifier is not available.

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  • Mains Noise Eliminators

    Signals recorded using biological amplifiers and other high impedance devices are often contaminated with 50 or 60 Hz mains noise, leading to corruption of the content of these electrophysiological signals and a degradation of the quality of subsequent data analysis.  Digitimer now manufactures the original single channel Humbug alongside our new multi-channel D400 Mains Noise Eliminator, available in 2,4 and 8 channel variants for effective removal of mains interference without signal distortion.

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  • Manipulators

    Narishige have a reputation for manufacturing high quality manipulation equipment used in many fields. We supply the full range of Narishige coarse and fine manipulators for electrophysiology and injection.

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  • MED64 Multi-Electrode Array Systems

    Digitimer represents Alpha MED Science Inc. and their range of multielectrode array (MEA) systems. Developed from the Panasonic MED64 system, Alpha MED now manufacture the most sensitive in vitro MEA systems available for extracellular electrophysiology.

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  • Perfusion Equipment

    Automate Scientific design and manufacture a range of automated perfusion equipment for in vitro drug application or gravity fed in vivo fixation devices. Products include heated and pressurised perfusion systems and a range of compatible accessories.

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  • Pipette Fabrication

    Digitimer supplies a wide range of pipette fabrication tools and accessories (such as heater elements and glass) designed and manufactured by Narishige.  Products include vertical pipette pullers for patch-clamp and micro-injection; fire-polishers (microforges) and electrode grinders.

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  • Programmers & Timers

    Digitimer offers two hardware solutions for the delivery of repetitive trigger pulses to control our range of electrical stimulators or other devices.  The DG2A Train/Delay Generator is a simple, battery-powered trigger source, with several operating modes. The DG2A is also useful for determining effective refractory period through use of a delayed second pulse. More advanced timing protocols can be developed using our modular NeuroLog System, which can operate as a multi-purpose pulse generator. Using appropriate modules, complex pulse and/or TTL trigger patterns can be produced.

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  • Signal Generators

    Digitimer recommends Thurlby Thandar function generators for use with our D179 Performance Checker. The D179 is capable of attenuating a calibrated output from one of the function generators below, so it can be fed into a clinical amplifier system.

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  • Software

    Digitimer supplies a range of software packages for use with many of our hardware products, incliding AutoMate Scientific (ValveBank). We are also the sole source of the specialist QtracW nerve excitability/threshold tracking software and QTMS extension.

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  • Stimulators

    As a leading supplier of products for life science and neurophysiological research, we manufacture and stock a diverse range of stimulators – including constant current and constant voltage stimulators, low-noise stimulus isolators, and multi-channel stimulators for human and clinical use.
    These are all innovative, high-quality devices, available at very competitive prices. Whatever the nature of your latest research study, we’re almost certain to have a stimulator that meets your needs.Browse our full collection today, and if you have any questions – or would like tailored advice on the best electric stimulator for your application – please don’t hesitate to contact our experts. [vc_tta_accordion active_section="0" collapsible_all="true"][vc_tta_section title="Why shop with us for stimulators?" tab_id="1645615373920-f10d4f90-d20e"][vc_column_text]Digitimer Ltd has an international reputation for high-quality electrical stimulators. Our devices are used all over the world for electrophysiological applications, both in clinical and biomedical research areas, and we always strive to push the boundaries with our product range. Over the last 40 years, we have honed our skills in this area and created a fantastic selection of stimulators to meet our clients’ needs. Nevertheless, we’re still committed to product development and continuously work alongside universities and hospitals to develop new innovative devices. The latest of which includes the DS8R – a multi-mode constant current stimulator, designed for human research and regarded as the ‘next generation’ of muscle and nerve stimulation. All of our stimulators are CE certified and either meet or exceed required standards. As an ISO 13485 certified manufacturer, we have extensive experience within the area of medical device design, development and manufacture. Furthermore, client satisfaction is at the heart of everything we do. Our prices are competitive and we pride ourselves on our excellent pre- and post-sales service.[/vc_column_text][/vc_tta_section][vc_tta_section title="Which stimulator is right for me?" tab_id="1645615373927-6ff4f2e6-993e"][vc_column_text] Due to the wide range and complexity of devices now available, we appreciate that choosing the right medical or human research stimulator for your needs may not be the easiest decision. We always aim to make our stimulators as general-purpose as possible. But inevitably, some devices are better suited to certain applications than others. And the best device for you will depend on several factors, including the nature of your research, how/where you intend to use it and more. When selecting an electric stimulator, some of the most important things to consider include:
    • Output current range
    • Output resolution and accuracy
    • Compliance voltage
    • Pulse duration
    • Output pulse shape
    • Polarity, biphasic or charge-balanced output
    • Hardware and software control methods
    If you’re unsure, our product brochure can be a helpful place to start. This includes a detailed summary of all the stimulator devices currently available and lists the key features of each. It’s also worth taking a look at our ‘Guide to Digitimer’s range of isolated electrical stimulators’. Not only does this comprehensively explain the features listed above, it also includes a useful downloadable table, which summarises the main characteristics of several of our stimulator models – including the DS5, DS7A & DS7AH, DS7R and, the latest addition to our collection, the DS8R. For further information and tailored advice on the most appropriate device for your needs, you’re also welcome to contact us at any time. Just get in touch via our website or give us a call.[/vc_column_text][/vc_tta_section][vc_tta_section title="Are our stimulators suitable for human research?" tab_id="1645615373927-6ff4f2e6-993f"][vc_column_text]Yes. Some are designed and manufactured specifically for use in human research settings, whilst other electric stimulator models are only suitable for animal or in vitro use. Of those which are safe for use with human subjects, several have been medically certified. For example, the DS7R and DS8R are both designated as human research devices. They’re compliant with many of the relevant international medical device and safety standards, but due to their versatile features and specifications, we’re unable to seek medical certification for these stimulators. By contrast, the D185, DS5, DS7AP, DS7A and DS7AH have all received medical certification in the UK, EU and several other countries. The D185, DS7AP and DS7A/DS7AH also have FDA 510(k) clearing for marketing in the USA. It’s important to note that, devices that are only intended for human research – rather than clinical use – do not need to be medically approved. Certification can sometimes make it easier for your research to gain ethical approval. But if a research device is favoured for your project, we can support your ethical approval application with technical documentation relating to its safety. More information on the use of non-medically certified stimulators can be found in our blog ‘Is a medical device necessary for my study?’. But if you have any questions, please don’t hesitate to get in touch with our experts. Either call us on 01707 328347 or send an email to [email protected].[/vc_column_text][/vc_tta_section][vc_tta_section title="Do our stimulators come with a warranty?" tab_id="1645615373927-6ff4f2e6-993g"][vc_column_text]Here at Digitimer, we take great pride in the quality of our products. All of our stimulators undergo a rigorous design, manufacture and testing process – therefore faults and failures are highly unlikely. Having said that, constant current and constant voltage stimulators are complex devices made from hundreds of parts (sourced from a range of suppliers). Which means, there’s always a small chance that – at some point in the device’s lifetime – an unexpected fault or issue may occur. We appreciate that an electric stimulator is a significant investment for most research studies. Which is why, we offer a free 1-year manufacturer’s warranty with each model as standard. In addition, we offer the opportunity to register for a complimentary 2-year warranty – up to 28 days from the point of delivery. And for a small extra charge, you can now extend this to 5 years. Please note, these warranties do not cover general wear and tear, or damage caused by incorrect use or mishandling of the stimulator. But they do cover all manufacturing defects and electronic component failures and can provide peace of mind that your new device is properly protected.[/vc_column_text][/vc_tta_section][vc_tta_section title="How much will an electrical stimulator cost?" tab_id="1645615373927-6ff4f2e6-993h"][vc_column_text]This depends on the type of stimulator you require and can range from a few hundred to several thousand pounds. The manufacturer’s Net List Price for each stimulator is displayed below. But please note, this excludes UK VAT and shipping costs, and international pricing will be influenced by exchange rates, local taxes, import charges, operational costs, shipping and packing. To get a better idea of the cost of your chosen stimulator, the best option is to request a quote. Simply add the device to your ‘quote list’ and provide a few details, including how you intend to use the equipment. A member of the team will then respond to your enquiry, with application-specific recommendations and an accurate quote – in either GB Pounds, US Dollars, or Euros. Alternatively, to find out more about our stimulators and their associated costs, you’re welcome to call us at any time. Simply dial 01707 328347 for UK enquiries or (954) 334-1070 for US enquiries.[/vc_column_text][/vc_tta_section][vc_tta_section title="How do I buy an electric stimulator?" tab_id="1645615507131-9c13d892-be2c"][vc_column_text]Our electrical stimulators are not currently available for online purchase. Due to the complex nature of these devices, we ask potential customers to first make an enquiry or request a quote. Just submit our online quote form, give us a call, or send an email to [email protected]. Once we have received your enquiry, a member of the team will respond as soon as possible with further information – including specific application recommendations, tailored advice on the best stimulator for your requirements and the estimated cost of your requested equipment. If you wish to go ahead with the purchase, please submit a purchase order to our team via mail or e-mail.[/vc_column_text][/vc_tta_section][/vc_tta_accordion]

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  • D330 MultiStim System

    The modular MultiStim System has been designed for use in laboratories where several in vitro preparations in tissue baths or cell culture wells require field stimulation from a low-impedance source. The system uses a common timing waveform for each channel but different stabilised stimuli to each preparation. The system includes modules for constant voltage and constant current stimulation.
    D330 Multistim rack

    High Current or Voltage Stimulation

    The system provides a choice of either constant voltage stimulation (up to 100V at 1A - D333H) or constant current stimulation (up to 500mA from a 100V source - D343).

    Built-in Stimulus Monitoring

    The D335 - Meter can be fitted into the system to allow precise voltage or current monitoring.

    Internal or External Timing Capabilities

    A selection of timing modules are available to generate pulses, variable in frequency and width, which can be controlled as bursts using a gating waveform, variable in repetition rate and duration or pulse count. Sockets are fitted to allow full external control and synchronisation if required.

    Bench Top or Rack Mountable

    The D330-MultiStim System rack/case is available in a 19" rack-mountable unit - D337, that can house the Gated Pulse Train Generators and up to ten stimulation channels.

    Modular Solution for Changing Requirements

    The modularity of the system allows a system to be extended or split between smaller units for two sites.

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