DS3 Isolated Current Stimulator

DS3 Isolated Current Stimulator

£1,100.00 exc. VAT

Manufacturer's Net List Price

FEATURES

  • Low noise battery power supply with 90V compliance
  • Internal (20µs to 2s) or external TTL “gated” control of pulse duration
  • Four current ranges allow precise reproducible control of stimulus output between 2µA and 32mA
  • Polarity reversal switch
  • Battery test sockets
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Description

DESCRIPTION

The DS3 provides a precise constant current, isolated stimulus, controllable in pulse duration and amplitude from self-contained batteries. The range of pulse durations available can be varied using a six-position switch and multiplier within the range 20 microseconds to 2 seconds as well as being externally controlled (gated). A three-turn dial on the front panel of the stimulator provides a continuous adjustment of the output amplitude which is indicated on the vernier dial as 0.2 to 3.2. With the four ranges (x10μA; x100μA; x1mA and x10mA), currents from 2μA to 32mA can be selected. The existence of an output pulse is indicated by an LED. The Output is optically isolated from the trigger source ensuring a very low capacitive coupling between trigger source and stimulator to reduce artifacts. The self-contained batteries, without a DC-DC converter, ensure that the stimulator is ultra-quiet and does not induce any high-frequency noise into the recording system.

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DOWNLOADS

 

DS2A/DS3 Isolated Stimulator
Data sheet

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DS3 Application Note
Using two DS3 stimulators in parallel allows stimulation through the same electrodes with different pulse types

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DS3 Application Note
Using a DG2A Train/Delay Generator & Two DS3 Isolated Stimulators to Produce a Biphasic Constant Current Stimulus

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DS3 Isolated Stimulator
Operator’s Manual

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DOWNLOAD BROCHURE

Digitimer-Life-Science-Brochure-1

PUBLICATIONS

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G Tsotsokou, A Miliou, G Trompoukis… , 2024 , Region-Related Differences in Short-Term Synaptic Plasticity and Synaptotagmin-7 in the Male and Female Hippocampus of a Rat Model of Fragile X Syndrome , International Journal of …
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V Krotov, P Belan, N Voitenko , 2024 , Approach for Electrophysiological Studies of Spinal Lamina X Neurons , Bio-protocol
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AI Melo, R Zempoalteca… , 2024 , Role of tactile stimulation during the preweaning period on the development of the peripheral sensory sural (SU) nerve in adult artificially reared female rat , Developmental …
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K Lee, Y Jung, Y Vyas, Z Mills… , 2024 , Differential effectiveness of dietary zinc supplementation with autism-related behaviours in Shank2 knockout mice , Philosophical …
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L Simões de Oliveira, HE O'Leary, S Nawaz… , 2024 , Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder , Molecular Autism
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AS Butler, R Ascione, NV Marrion, SC Harmer… , 2024 , In situ monolayer patch clamp of acutely stimulated human iPSC-derived cardiomyocytes promotes consistent electrophysiological responses to SK channel … , Scientific Reports
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SS Kristensen, K Kesgin, H Jörntell , 2024 , High-dimensional cortical signals reveal rich bimodal and working memory-like representations among S1 neuron populations , Communications biology
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S Anders, B Breithausen, P Unichenko, MK Herde… , 2024 , Epileptic activity triggers rapid ROCK1‐dependent astrocyte morphology changes , Glia
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JB Winther, JJ Morgen, M Skov, MG Broch-Lips… , 2024 , Role of recovery of acetylcholine release in compromised neuromuscular junction function , Neuromuscular …
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AR Giniatullin, KA Mukhutdinova, AM Petrov , 2024 , Mechanism of Purinergic Regulation of Neurotransmission in Mouse Neuromuscular Junction: The Role of Redox Signaling and Lipid Rafts , Neurochemical Research
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LJ Kreeger, S Honnuraiah, S Maeker, S Shea, G Fishell… , 2024 , An Anatomical and Physiological Basis for Coincidence Detection Across Time Scales in the Auditory System , bioRxiv
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JCB Jacobsen, IH Schubert, K Larsen… , 2024 , Preload dependence in an animal model of mild heart failure with preserved ejection fraction (HFpEF) , Acta …
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SL Mondragón-González, C Schreiweis… , 2024 , Closed-loop recruitment of striatal interneurons prevents compulsive-like grooming behaviors , Nature …
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H Londoño‐Ramírez, X Huang, J Cools… , 2024 , Multiplexed Surface Electrode Arrays Based on Metal Oxide Thin‐Film Electronics for High‐Resolution Cortical Mapping , Advanced …
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M Alves, B Gil, J Villegas-Salmerón, V Salari… , 2024 , Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice , Brain, Behavior, and …
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M Skov, TQ Ruijs, TS Grønnebæk, M Skals… , 2024 , The ClC-1 chloride channel inhibitor NMD670 improves skeletal muscle function in rat models and patients with myasthenia gravis , Science translational …
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DC Malloy, MP Côté , 2024 , Multi-session transcutaneous spinal cord stimulation prevents chloride homeostasis imbalance and the development of hyperreflexia after spinal cord injury in … , Experimental neurology
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GJ Duncan, SD Ingram, K Emberley, J Hill… , 2024 , Remyelination protects neurons from DLK-mediated neurodegeneration , Nature …
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Y Liao, BS Muntean , 2024 , KCTD1 regulation of Adenylyl cyclase type 5 adjusts striatal cAMP signaling , Proceedings of the National Academy of Sciences
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SS Kristensen, H Jörntell , 2024 , Local field potential sharp waves with diversified impact on cortical neuronal encoding of haptic input , Scientific Reports
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X Cui, W Wei, Z Zhang, K Liu, T Zhao, J Zhang… , 2024 , Caffeine impaired acupuncture analgesia in inflammatory pain by blocking adenosine A1 receptor , The Journal of …
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S Früh, S Boudkkazi, P Koppensteiner, V Sereikaite… , 2024 , Monoallelic de novo AJAP1 loss-of-function variants disrupt trans-synaptic control of neurotransmitter release , Science …
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ACCESSORIES

Supplied

  • Operator’s Manual
  • One set of batteries (fitted)
  • One Pair of output plugs (NL985P)

Recommended

FAQs

▼ I want to stimulate with a longer pulse duration than 2 seconds, in order to lesion some tissue, is it possible to do this?
Yes, there are two simple methods. (i) The DS3 has the ability to be gated by an external pulse i.e. when external control of pulse duration is selected the output stimulus timing will be controlled by the trigger-in stimulus pulse. It should be noted that (with a 5V input pulse) there is only a very short delay of <2µs for the turn-on and <6µs for the turn-off. When a typical TTL pulse is used, which will only be about 3V, these are matched at 4µs each. (ii) Alternatively, if a trigger pulse is not available or exact timing is not crucial (for instance when lesioning or injecting dye, there is a jumper which can be set to allow the unit to deliver a current for the duration the single shot button is held down. The internal SINGLE jumper determines the output delivered when the SINGLE button is pressed (when EXTERNAL Duration is selected). MON (factory setting) produces a very short pulse ~10µs when pressed. CONT produces an active output for the duration of the press. This could be useful in dye marking etc.
▼ Can I control the DS3 or DS2A using a computer?
Yes and no. The DS3 features an external GATE input allowing externally derived trigger pulses to define stimulus duration. However, the output amplitude is always determined by the front panel setting of the stimulator. We recommend our NeuroLog system to those interested in using a computer generated waveform to define stimulus timing/polarity and strength.
▼ I can’t decide between the constant current DS3 and constant voltage DS2A MkII- how should I choose?
The visible difference between the two units (apart from the colour!) is that the output control of the DS2A is defined in Volts while the output of the DS3 is defined in Amps. The actual stimulus passing through your preparation is measured in Amps in both cases and is dependent upon Ohms Law (V = IR). If your preparation has a variable impedance (R) and you are using a constant voltage (V) source such as the DS2A, then the actual current (I) passing through the tissue may vary considerably between each stimulus, which may not be a good idea if you want to apply reproducible stimuli. With the DS3, the constant current circuitry prevents variations in tissue impedance from altering the size of current applied (within the 90V compliance limit of the unit), leading to the stimulator equivalent of WYSIWYG – “What You Set Is What You Get”. Unfortunately there are no well defined rules governing the circumstances under which either stimulator should be used. If you are not sure and feel the need to evaluate either or both please contact us.
▼ If the DS2A or DS3 is connected to the TTL generating device which is grounded, will the stimulus delivered be still isolated? In other words, would it be safe to use it with patch-clamp, or there is a risk of destroying of the patch-amplifier?
Absolutely. The output of the DS2A or DS3 is optically isolated from the trigger inputs, so there is no need to worry about what your trigger source is, or how it is grounded.
▼ Can the DS2A, DS3 or DS4 be used to stimulate human subjects?
Neither the DS2A, DS3 nor DS4 have medical device directive (MDD) certification and have not been designed for safe human use. We offer a range of medical device compliant stimulators for patient connection as well as a range of stimulators designed for safety in human research studies.
▼ How long do the batteries last for and can I use rechargeable replacements?
Battery life will depend on the frequency of operation and will therefore vary widely with the application, but the following example may be considered typical. Output current – 20mA, duty cycle – 1:10, period of operation – 2 hours/day. Estimated life to end point voltage of 6V per 9V battery – 2 months. In in vitro electrophysiology applications, the battery life will most likely be far longer as the currents being used will be lower. Replacement batteries should be of premium grade sealed type, alkaline preferred and batteries should not be left in an unused stimulator. Rechargeable batteries are not recommended, as their voltages tend to decline very suddenly, which could lead to a failure in the middle of an experiment.
▼ What is the maximum trigger rate of the DS2A or DS3?
The unit can be triggered fast enough to allow >99% “on” time, but the “off” time must >20 microseconds – so, very fast!
▼ I have an old DS2 constant voltage stimulator and I recall that Digitimer offer a conversion to constant current. Is this still possible?
No, Digitimer no longer offers this service. Since the introduction of the new DS3 constant current stimulator, this unit is now offered to customers requiring a constant current version of the DS2A.
▼ Is it possible to use two DS3 stimulators in parallel in order to stimulate through the same electrodes with different pulse types?
Yes, this is quite simple to setup and has been summarized in an application note
▼ What is the frequency at which the pulses are delivered when the trigger button is pressed in conditions when jumper is set to cont?
The trigger button has no effect of trigger frequency. It is designed to allow the user to press and hold the Trigger Button to deliver a continuous single stimulation pulse while it is held down. This can be useful for electrical lesioning of a recording site once an experiment is complete.
▼ Are any of your stimulators MRI compatible?
Our stimulators are not classed as MRI safe, as all of them contain ferrous materials which means they cannot be used within a magnetic field. However, as long as they are located beyond the reach of magnetic field or in the scanner control room they may be used. It is important that MRI compatible electrodes and cables are used within the scanner room.

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