Description
DESCRIPTION
The DS5 Isolated Bipolar Constant Current Stimulator allows computer control of stimulus amplitude and timing parameters and has a maximum constant current output of ±50mA. It was originally designed to speed up and enhance human peripheral nerve diagnostics by facilitating semi-automated nerve excitability tests. However, it also has roles in wider aspects of clinical neurophysiology research, including psychological, vestibular system and nociceptive testing. More recently pairs of DS5’s have been used in research investigating the new technique of temporal interference stimulation (TIS), which may offer a non-invasive, but targeted alternative to deep brain stimulation and other therapies. The DS5 Isolated Bipolar Constant Current Stimulator is a CE marked medical device under the European Medical Device Regulation.
The DS5 is controlled by an analogue voltage input or “command” signal which it translates into an isolated constant current stimulus (up to ±50mA), precisely replicating the shape of the input waveform. As a result the DS5 should be of interest to anyone wishing to control surface electrical stimulation protocols via software/hardware combinations capable of producing a suitable command voltage waveform e.g semi-automated pain research or sensory threshold testing. The DS5 has also been employed for galvanic vestibular stimulation (GVS), transcranial AC stimulation (tACS) and temporal interference stimulation (tIS) protocols.
The DS5 was developed in collaboration with Prof. Hugh Bostock (UCL, London) for use with QtracW, a nerve excitability stimulus control, acquisition and data analysis software package, also available from Digitimer. This software semi-automates tests of nerve, muscle or cortical excitability using threshold tracking methods.
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PUBLICATIONS
The Digitimer DS5 Bipolar Constant Current Isolated Stimulator has been referenced in over 500 research papers, which can be viewed on Google Scholar. A few of the most highly cited papers published since 2019 are provided below.
Al, E., Iliopoulos, F., Forschack, N., Nierhaus, T., Grund, M., Motyka, P., … Villringer, A. (2020). Heart-brain interactions shape somatosensory perception and evoked potentials. Proceedings of the National Academy of Sciences of the United States of America, 117(19), 10575–10584. https://doi.org/10.1073/pnas.1915629117
Asamoah, B., Khatoun, A., & Mc Laughlin, M. (2019). tACS motor system effects can be caused by transcutaneous stimulation of peripheral nerves. Nature Communications. nature.com. https://doi.org/10.1038/s41467-018-08183-w
Engelmann, J. B., Meyer, F., Ruff, C. C., & Fehr, E. (2019). The neural circuitry of affect-induced distortions of trust. Science Advances. advances.sciencemag.org. https://doi.org/10.1126/sciadv.aau3413
Hird, E. J., Charalambous, C., El-Deredy, W., Jones, A. K., & Talmi, D. (2019). Boundary effects of expectation in human pain perception. Scientific Reports. nature.com. https://doi.org/10.1038/s41598-019-45811-x
Hoskin, R., Berzuini, C., Acosta-Kane, D., El-Deredy, W., Guo, H., & Talmi, D. (2019). Sensitivity to pain expectations: A Bayesian model of individual differences. Cognition. Elsevier. https://doi.org/10.1016/j.cognition.2018.08.022
Keywan, A., Jahn, K., & Wuehr, M. (2019). Noisy Galvanic Vestibular Stimulation Primarily Affects Otolith-Mediated Motion Perception. Neuroscience, 399, 161–166. https://doi.org/10.1016/j.neuroscience.2018.12.031
Sarigiannidis, I., Grillon, C., Ernst, M., Roiser, J. P., & Robinson, O. J. (2020). Anxiety makes time pass quicker while fear has no effect. Cognition. Elsevier. https://doi.org/10.1016/j.cognition.2019.104116
van Alst, T. M., Wachsmuth, L., Datunashvili, M., Albers, F., Just, N., Budde, T., & Faber, C. (2019). Anesthesia differentially modulates neuronal and vascular contributions to the BOLD signal. NeuroImage. Elsevier. https://doi.org/10.1016/j.neuroimage.2019.03.057
Wang, Y., Ge, J., Zhang, H., Wang, H., & Xie, X. (2020). Altruistic behaviors relieve physical pain. Proceedings of the National Academy of Sciences of the United States of America, 117(2), 950–958. https://doi.org/10.1073/pnas.1911861117
van Alst, T. M., Wachsmuth, L., Datunashvili, M., Albers, F., Just, N., Budde, T., & Faber, C. (2019). Anesthesia differentially modulates neuronal and vascular contributions to the BOLD signal. NeuroImage. Elsevier. https://doi.org/10.1016/j.neuroimage.2019.03.057
ACCESSORIES
Supplied
- Mains (Power) lead
- Operator’s Manual
- USB Cable
Recommended
- D185-HB4 Output Extension Cable
- D185-OC1 – Output Plugs
- Electrodes and electrode adaptor leads
