Research and Clinical Instruments Manufacturer & Supplier
Acquisition InterfacesNational Instruments USB-6341-BNCHEKA LIH 8+8 Data Acquisition SystemAmplifiersNeuroLog SystemD360 8-Ch. EP/EEG/EMGD360R 4 Channel Isolated Research Amplifier/FilterD440 2/4 Ch. EMG/EPHEKA EPC10 Patch ClampHEKA EPC10 2/3/4 Ch. Patch ClampHEKA EPC800 Patch ClampAnti-vibration SystemsThorLabs Science DesksNarishige ITS Anti-vibrationNarishige Double MagnetNarishige SBP-2 BaseplateCell InjectorsPLI-100A Pico-injectorPLI-10 Pico-injectorNarishige IM-11-2Narishige IM-9BNarishige IM-9CNarishige IM-6Narishige IM-400Injection Accessories
Incubators & ChambersAutomate Perfusion ChambersMedical Systems MicroincubatorsSSD Brain Slice ChambersIontophoretic DevicesD380 Dye MarkerMains Noise EliminatorsHumBug Noise EliminatorD400 Mains Noise EliminatorManipulatorsElectrophysiology System ManipulatorsInjection System ManipulatorsStereotaxic Manipulators“YOU” Compact ManipulatorsChronic ManipulatorsAccessoriesMicroscope Adaptors
MEA SystemsMED64 – BasicMED64 – Quad IIMED64 – AllegroMED64 – Plex 4/8MED64 – PrestoMED64 – Mobius SoftwareMED64 ProbesPerfusion SystemsStandard & Pressurized PerfusionSmartSquirt Micro-PerfusionIn Vivo Perfusion (Fixation)Heated PerfusionPipette FabricationMicropipette PullersMicroforges & MicrogrindersReplacement PartsCapillary GlassProgrammers & TimersDG2A Train Delay GeneratorNeuroLog System
Signal GeneratorsTG315 Function GeneratorSoftwareQtracW Threshold TrackingAutoMate EasycodeHEKA Chartmaster SoftwareHEKA Patchmaster SoftwareHEKA Fitmaster SoftwareStimulatorsDS2A Constant VoltageDS3 Constant CurrentDS4 Biphasic Constant CurrentDS5 Bipolar Constant CurrentDS7A/DS7AH Constant CurrentDS7R Constant Current ResearchDS8R Biphasic ResearchD121-11 Mounting FrameD185 Transcranial MultiPulseD330 MultiStim SystemNL800A Current Stimulus Isolator
A/D Interface ModulesNL201 – Spike TriggerNL601 – Pulse IntegratorAmplifier ModulesNL100AK – HeadstageNL100RK (NL100AKS & NL100C)NL102G – DC PreamplifierNL104A – AC PreamplifierNL106 – AC/DC AmplifierNL108A – Pressure AmplifierNL109 – Bridge AmplifierNL120S – Audio AmplifierNL820A – IsolatorNL822 – Two Channel AC PreamplifierNL844 – Four Channel AC PreamplifierAnalogue ModulesNL254 – RatemeterNL506 – Analogue SwitchNL703 – EMG Integrator
Digital ModulesNL405 – Width/DelayNL501 – Logic GateNL505 – Flip FlopNL603 – CounterNL730 – Pulse ShiftFilter & Conditioner ModulesNL125/6 – Band-Pass FilterNL134/5/6 – Four Channel Low Pass FiltersNL143 – Three Channel Difference AmplifierNL144 – Four Channel High Pass FilterNL530 – Signal ConditionerNL540 – Inverting Attenuator (Alt. Gain)Generator ModulesNL301 – Pulse GeneratorNL304 – Period GeneratorNL412 – Pulse
Neurolog AccessoriesAccessory KitsAdaptors & Adaptor CablesSockets (for cable mounting)Sockets (for panel mounting)Plugs (for cable mounting)Extension CablesCablesElectrode HoldersMiscellaneous ItemsNeurolog System CasesNL900D NeuroLog System CaseNL905 Compact NeuroLog System Case
Pressure Transducers & AccelerometersPressure TransducersForce TransducersAccelerometersStimulator ModulesNL510 – Pulse BufferNL512 – Biphasic BufferNL800A Constant Current Stimulus IsolatorNeurolog System Application NotesSignal AmplificationTriggering & Pulse GenerationSignal Conditioning Filtering & ProcessingElectrical Stimulation
Amplifier Accessories D175 Electrode Impedance Meter D179 Performance Checker D360 Audio Interface D360 USB to Serial Adaptor D177 Bio-Feedback Unit Isolated Amplifiers for EMG / EEG D440 2 or 4 Channel Isolated Amplifier D360 8-Channel Patient Amplifier D360R 4 Channel Research Amplifier
Neurodiagnostic AccessoriesIntraoperative Monitoring (IOM) and Electroencephalography (EEG) Electromyography (EMG)Nerve Conduction Study (NCS) Evoked Potential (EP)Axelgaard Stimulation ElectrodesTouch Proof Plugs Adaptors & Electrode Linkers
Peripheral Stimulators DS5 Isolated Bipolar Constant Current Stimulator DS7A & DS7AH HV Constant Current Stimulator NEW DS7R HV Constant Current Research Stimulator NEW DS8R Biphasic Constant Current Stimulator
Stimulator AccessoriesD188 Remote Electrode SelectorElectrode Connection HeadboxesTrigger CablesElectrode HandlesMiscellaneous ItemsTranscranial Cortical StimulatorsD185 MultiPulse Cortical Electrical Stimulator
Cath SecureCATH-SECURE – OriginalCATH-SECURE – ExtendedCATH-SECURE PlusCATH-SECURE – Dual TabCATH-SECURE For KidsNG SECURE
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Urodynamic ConsumablesUrodynamics CathetersPump Infusion SetsTransducer Pressure DomesUrodynamic Consumables Accessories
Now used worldwide as an effective tool for intraoperative monitoring (IOM) of the spinal cord, the D185 MultiPulse Cortical Electrical Stimulator is the ONLY standalone surgical stimulator with FDA clearance for this technique.
The D185 MultiPulse Cortical Electrical Stimulator allows transcranial motor evoked potentials (MEPs) to be used in surgical procedures such as scoliosis correction, spinal tumour resection and thoraco-abdominal aortic aneurysm (TAAA) repair. The 1000V power source means that MEPs can even be evoked in patients with pre-existing neuropathologies.
The D185 MultiPulse Cortical Electrical Stimulator is also useful for peripheral nerve stimulation. Although the D185 was designed for transcranial cortical stimulation during intraoperative monitoring, the brief high voltage output also makes it suitable for use as a spinal root stimulator during differential diagnosis of peripheral nerve disorders, such as multifocal motor neuropathy and motor neuron disease. The high voltage allows effectively stimulation of deep nerve roots as they exit the spinal column, while the very short pulse duration minimizes patient discomfort.
Surgical procedures carried out within or near the spinal column or those involving transient interruption of blood flow to the spinal cord (e.g repair of thoraco-abdominal aortic aneurysms) are associated with a risk of neurological impairment ranging from loss of sensation to complete paraplegia. These deficits can arise as a result of direct trauma, stretching of nerves or occlusion of blood flow. Much effort has therefore been made to develop techniques which allow the health of the spinal cord to be assessed continuously during these risky surgical procedures.
Surgical teams currently monitor the status of ascending spinal sensory pathways by applying stimuli to the patient’s ankle or wrist and observing the resultant changes in somatosensory evoked potentials (SEP’s) recorded from the brain. This form of intra-operative monitoring uses changes in the SEP waveform to alert medical teams of possible complications and there is no doubt that this technique has protected many patients from surgically induced neurological deficits. However, the technique of SEP monitoring has attracted some criticism, much of which has been published in peer-reviewed journals:
Unchanged SEP waveforms have on occasions misled surgeons into continuing with surgery, resulting in unforeseen post-operative neurological complications such as severe paraplegia.
Altered SEP’s have prompted surgeons to back-off from procedures, only to find that the patient has suffered no loss in sensory status upon recovery.
As SEP’s are generally small in magnitude, they can be difficult to monitor reliably in some patients, particularly those presenting with a pre-existing neuropathology.
Although SEP monitoring is used as an indicator of the health of the spinal cord as a whole, some would argue that for anatomical reasons, the descending motor fibres may be at greater risk during surgery. This would suggest that it would be of tremendous benefit to monitor descending motor fibres exclusively or in combination with SEP monitoring.
In collaboration with leading clinical neurophysiologists, Digitimer developed the D185 MultiPulse Stimulator in order to provide a more reliable method of minimizing the risk of surgically induced paraplegia while maximizing the level of surgical correction that could be safely conducted. This unique device is used transcranially to electrically stimulate the brain’s motor cortex, resulting in a descending motor evoked potential (MEP) which is conducted down the spinal cord to upper and lower limb extremities. The pathways stimulated in this manner are the same as those used by the brain to trigger and control voluntary movement. As with SEP monitoring, any alterations in the MEP waveforms can provide the surgical staff with a crucial warning of possible complications.
A 1000 patient, 2 centre clinical trial of the Digitimer D185 in the USA, demonstrated that MEP monitoring during spinal surgery was (1) more accurate for predicting motor outcome than the SEP was for predicting sensory outcome; and (2) that useful motor responses were achievable with a higher probability than useful sensory responses. Furthermore, in cases where SEP monitoring alone may have misled the surgeon into aborting or curtailing a procedure, additional use of MEP monitoring was shown to more reliably indicate whether it was safe for the surgeon to complete a procedure. Evidence from the 5-year study outlined above prompted the FDA to clear the Digitimer D185 MultiPulse Stimulator for marketing and the technique of MEP monitoring is now utilised extensively by cardiovascular and neurosurgeons all over the world.
MultiPulse Stimulator D185 Mk.IIa
D185 Electrode Holders
D185 MEP Connection Headboxes
Insertion of D185 Stimulus Output Connector
Publications which cite use of the Digitimer D185 can be found on Google Scholar.
The D185 MultiPulse Cortical Electrical Stimulator can be supplied with a range of accessories to facilitate integration with your current operating theatre equipment and stimulation preferences. The current range includes electrode extension leads, stimulator output plugs, a footswitch and a range of electrode connection head boxes and electrode holders/handles for peripheral nerve stimulation applications.
The D185-HB4 Output Extension Cable provides an extension of the output sockets fitted to our range of clinical and human research stimulators.
DESCRIPTION D185-HB1 Electrode Connection Headbox (5m cable). This extension headbox provides 5 linked pairs of 1.5mm DIN sockets for connection
D185-HB3 Electrode Connection Headbox with stimulus reversal and SEP electrode disconnection (inc. D185-CB1) – 5m. Ideal for those using SEP
D185-TC5 Trigger Cable (BNC socket – 3.5mm) – 0.6m. For connection between your EP system and the D185.
D185-TC4 Trigger Polarity Inverter. For connection between your EP system and the D185.
D185-TC3 Trigger Cable (BNC – BNC) – 1m. For connection between your EP system and the D185.
D185-TC2 Trigger Cable (BNC – SMB) – 1.5m. For connection between your EP system and the D185.
DESCRIPTION D185-TC1 Trigger Cable (BNC – 3.5mm) – 1.5m. For connection between your EP system and the D185. GALLERY DOWNLOADS
D180-Pads – Pack of ten 12mm felt pads for use with the D180 and D185 Electrode Handles.
D185-OL1 Output Lead – moulded connector on 5m cable for user assembly. Also suitable for use with the DS7A peripheral
D185-OC1 Output Connector Plugs for user assembly (pair). Also suitable for use with the DS7A peripheral nerve/muscle stimulator.
D185-FS1 Foot Switch to IP68. Supplied with each DS7AP, this IP68 rated foot switch allows hands-free foot pedal control of stimulus delivery.
D185-EH4 D180ES Style Electrode – Single anode and single cathode with long handle (with 60mm spacing).
D185-EH3 Compact Standard Electrode – Single anode and single cathode (with 50mm spacing).
D185-EH2 Depth Electrode – One cathode and three anodes for deep peripheral nerve stimulation.
The D185 has certain safety limits that prevent excessive energy from being delivered to the patient. If you set the D185 to Normal mode and try to deliver too many pulses at too high a voltage, the unit will give an ERROR. You should consult the section titled Operating Modes in the D185 Operator’s Manual where you will find a graph that illustrated what these limits are.
Before you suspect any faults with the stimulator or cable, you should confirm that you have inserted the moulded plug of the extension cable correctly into the output socket on the front of the stimulator. When the plug mates with the output socket, it can be partly inserted with very little force, however, this does not provide a good electrical connection. For a complete electrical connection, further force is required and this supplement to the D185 users manual illustrates how the plug should be correctly inserted.
Yes, the D185-HB3 was specifically designed with this problem in mind. The D185-HB3 headbox incorporates 5 pairs of MEP output sockets as well as 6 channels of isolation for SEP electrodes. If the SEP electrodes are connected through the D185-HB3, they are briefly isolated while an MEP stimulus is passed. This prevents the EP system from “seeing” the MEP stimulus artefact and thus stops the amplifier from saturating/blocking for any length of time. You can read more about the D185-HB3 on the D185 page.
This is very much a decision that only you as the user can make, however we do supply a range of different accessories which start with the basic D185-HB4 which is essentially an output extension lead and end with the D185-HB3 which has 5 pairs of output sockets, a means of isolating SEP recording electrodes during MEP stimulus and a handheld trigger/polarity switching unit (D185-CB1) which allows the operator to easily trigger the D185. More detailed information on the accessories is available on the main D185 page.
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