Research and Clinical Instruments Manufacturer & Supplier
Acquisition InterfacesNational Instruments USB-6341-BNCHEKA LIH 8+8 Data Acquisition SystemAmplifiersNeuroLog SystemD360 8-Ch. EP/EEG/EMGD360R 4 Channel Isolated Research Amplifier/FilterD440 2/4 Ch. EMG/EPHEKA EPC10 Patch ClampHEKA EPC10 2/3/4 Ch. Patch ClampHEKA EPC800 Patch ClampAnti-vibration SystemsThorLabs Science DesksNarishige ITS Anti-vibrationNarishige Double MagnetNarishige SBP-2 BaseplateCell InjectorsPLI-100A Pico-injectorPLI-10 Pico-injectorNarishige IM-11-2Narishige IMS-20Narishige IM-21Narishige IM-400Injection Accessories
Incubators & ChambersAutomate Perfusion ChambersMedical Systems MicroincubatorsSSD Brain Slice KeepersSSD Brain Slice ChambersIontophoretic DevicesD380 Dye MarkerMains Noise EliminatorsHumBug Noise EliminatorD400 Mains Noise EliminatorManipulatorsElectrophysiology System ManipulatorsInjection System ManipulatorsStereotaxic Manipulators“YOU” Compact ManipulatorsChronic ManipulatorsAccessoriesMicroscope Adaptors (Ephys)Microscope Adaptors (Injection)
MEA SystemsMED64 – BasicMED64 – Quad IIMED64 – AllegroMED64 – Plex 4/8MED64 – PrestoMED64 – Mobius SoftwareMED64 ProbesPerfusion SystemsStandard & Pressurized PerfusionSmartSquirt Micro-PerfusionIn Vivo Perfusion (Fixation)Heated PerfusionPipette FabricationMicropipette PullersMicroforges & MicrogrindersReplacement PartsCapillary GlassProgrammers & TimersDG2A Train Delay GeneratorNeuroLog System
Signal GeneratorsTG315 Function GeneratorSoftwareQtracW Threshold TrackingAutoMate EasycodeHEKA Chartmaster SoftwareHEKA Patchmaster SoftwareHEKA Fitmaster SoftwareStimulatorsDS2A Constant VoltageDS3 Constant CurrentDS4 Biphasic Constant CurrentDS5 Bipolar Constant CurrentDS7A/DS7AH Constant CurrentDS7R Constant Current ResearchDS8R Biphasic ResearchD121-11 Mounting FrameD185 Transcranial MultiPulseD330 MultiStim SystemNL800A Current Stimulus Isolator
A/D Interface ModulesNL201 – Spike TriggerNL601 – Pulse IntegratorAmplifier ModulesNL100AK – HeadstageNL100RK (NL100AKS & NL100C)NL102G – DC PreamplifierNL104A – AC PreamplifierNL106 – AC/DC AmplifierNL108A – Pressure AmplifierNL109 – Bridge AmplifierNL120S – Audio AmplifierNL820A – 4-Ch. IsolatorNL844 – 4-Ch. AC PreamplifierAnalogue ModulesNL254 – RatemeterNL506 – Analogue SwitchNL703 – EMG Integrator
Digital ModulesNL405 – Width/DelayNL501 – Logic GateNL505 – Flip FlopNL603 – CounterNL730 – Pulse ShiftFilter & Conditioner ModulesNL125/6 – Band-Pass FilterNL134/5/6 – 4-Ch. Low Pass FiltersNL143 – 3-Ch. Difference AmplifierNL144 – 4-Ch. High Pass FilterNL530 – Signal ConditionerNL540 – Inverting Attenuator (Alt. Gain)Generator ModulesNL301 – Pulse GeneratorNL304 – Period GeneratorNL412 – Pulse
NeuroLog AccessoriesAccessory KitsAdaptors & Adaptor CablesSockets (for cable mounting)Sockets (for panel mounting)Plugs (for cable mounting)Extension CablesCablesElectrode HoldersMiscellaneous AccessoriesNeuroLog System CasesNL900D – NeuroLog System CaseNL905 – Compact NeuroLog System Case
Pressure Transducers & AccelerometersPressure TransducersForce TransducersAccelerometersStimulator ModulesNL510 – Pulse BufferNL512 – Biphasic BufferNL800A Constant Current Stimulus Isolator
Application NotesSignal AmplificationTriggering & Pulse GenerationSignal Conditioning Filtering & ProcessingElectrical Stimulation
Isolated Amplifiers for EMG/EEG/EP D440 2/4-Ch. EMG AmplifierD360 8-Ch. Patient Amplifier D360R 4-Ch. Research AmplifierAmplifier Accessories D175 Electrode Impedance Meter D179 Performance Checker D360 Audio Interface D360 USB to Serial Adaptor D177 Bio-Feedback Unit
Peripheral Stimulators DS5 Isolated Bipolar Constant Current Stimulator DS7A & DS7AH HV Constant Current Stimulator DS7R HV Constant Current Research Stimulator DS8R Biphasic Constant Current Stimulator
Transcranial Cortical StimulatorsD185 MultiPulse Cortical Electrical StimulatorStimulator AccessoriesD188 Remote Electrode SelectorElectrode Connection HeadboxesTrigger CablesElectrode HandlesMiscellaneous Items
Neurodiagnostic AccessoriesIntraoperative Neuromonitoring (IONM) Electroecephalography (EEG) Electromyography (EMG)Nerve Conduction Study (NCS) Evoked Potential (EP)Axelgaard Stimulation ElectrodesTouch Proof Plugs Adaptors & Electrode Linkers
Cath SecureCATH-SECURE – OriginalCATH-SECURE – ExtendedCATH-SECURE PlusCATH-SECURE – Dual TabCATH-SECURE For KidsNG SECURE
PessariesPessary Ring Sizing KitsCerclage Pessary (Perforated)Cerclage Pessary (Non Perforated)Ring PessaryThick Ring PessaryCube Pessary (Perforated)Cube Pessary (Non-Perforated)Vaginal DilatorUrethra PessaryBowl PessarySieve Bowl PessaryHodge PessaryClub PessaryTandem Pessary (Perforated)Tandem Pessary (Non-Perforated)
Urodynamic ConsumablesUrodynamics CathetersPump Infusion SetsTransducer Pressure DomesFemale Voiding AdaptorDuckbill ValvesSetguards3-Way Taps
Manufacturer's Net List Price
The DS5 Isolated Bipolar Constant Current Stimulator allows computer control of stimulus amplitude and timing parameters and has a maximum constant current output of ±50mA. It was originally designed to speed up and enhance human peripheral nerve diagnostics by facilitating semi-automated nerve excitability tests. However, it also has roles in wider aspects of clinical neurophysiology research, including psychological, vestibular system and nociceptive testing. The DS5 Isolated Bipolar Constant Current Stimulator is a CE marked medical device under the European Medical Device Regulation.
The DS5 is controlled by an analogue voltage input or “command” signal which it translates into an isolated constant current stimulus (up to ±50mA), precisely replicating the shape of the input waveform. As a result the DS5 should be of interest to anyone wishing to control surface electrical stimulation protocols via software/hardware combinations capable of producing a suitable command voltage waveform e.g semi-automated pain research or sensory threshold testing. The DS5 has also been employed for galvanic vestibular stimulation (GVS) and transcranial AC stimulation (tACS) protocols.
The DS5 was developed in collaboration with Prof. Hugh Bostock (UCL, London) for use with QtracW, a nerve excitability stimulus control, acquisition and data analysis software package, also available from Digitimer.
DS5 Isolated Bipolar Stimulator Data Sheet
DS5 Control Software Installation Guide
Use of the DS5 Bipolar Constant Current Stimulator with the D188 Remote Electrode Selector.
Typical Equipment Setup for DS5/QtracW Installation
The Digitimer DS5 Bipolar Constant Current Isolated Stimulator has been referenced in over 500 research papers, which can be viewed on Google Scholar. A few of the most highly cited papers published since 2019 are provided below.
Al, E., Iliopoulos, F., Forschack, N., Nierhaus, T., Grund, M., Motyka, P., … Villringer, A. (2020). Heart-brain interactions shape somatosensory perception and evoked potentials. Proceedings of the National Academy of Sciences of the United States of America, 117(19), 10575–10584. https://doi.org/10.1073/pnas.1915629117
Asamoah, B., Khatoun, A., & Mc Laughlin, M. (2019). tACS motor system effects can be caused by transcutaneous stimulation of peripheral nerves. Nature Communications. nature.com. https://doi.org/10.1038/s41467-018-08183-w
Engelmann, J. B., Meyer, F., Ruff, C. C., & Fehr, E. (2019). The neural circuitry of affect-induced distortions of trust. Science Advances. advances.sciencemag.org. https://doi.org/10.1126/sciadv.aau3413
Hird, E. J., Charalambous, C., El-Deredy, W., Jones, A. K., & Talmi, D. (2019). Boundary effects of expectation in human pain perception. Scientific Reports. nature.com. https://doi.org/10.1038/s41598-019-45811-x
Hoskin, R., Berzuini, C., Acosta-Kane, D., El-Deredy, W., Guo, H., & Talmi, D. (2019). Sensitivity to pain expectations: A Bayesian model of individual differences. Cognition. Elsevier. https://doi.org/10.1016/j.cognition.2018.08.022
Keywan, A., Jahn, K., & Wuehr, M. (2019). Noisy Galvanic Vestibular Stimulation Primarily Affects Otolith-Mediated Motion Perception. Neuroscience, 399, 161–166. https://doi.org/10.1016/j.neuroscience.2018.12.031
Sarigiannidis, I., Grillon, C., Ernst, M., Roiser, J. P., & Robinson, O. J. (2020). Anxiety makes time pass quicker while fear has no effect. Cognition. Elsevier. https://doi.org/10.1016/j.cognition.2019.104116
van Alst, T. M., Wachsmuth, L., Datunashvili, M., Albers, F., Just, N., Budde, T., & Faber, C. (2019). Anesthesia differentially modulates neuronal and vascular contributions to the BOLD signal. NeuroImage. Elsevier. https://doi.org/10.1016/j.neuroimage.2019.03.057
Wang, Y., Ge, J., Zhang, H., Wang, H., & Xie, X. (2020). Altruistic behaviors relieve physical pain. Proceedings of the National Academy of Sciences of the United States of America, 117(2), 950–958. https://doi.org/10.1073/pnas.1911861117
The DS5 has been designed to be as versatile as possible and therefore it should be compatible with most D/A hardware and software. The DS5 merely requires an analogue input of ±1, ±2.5, ±5 or ±10V at the BNC socket on the rear to provide the waveform which describes the stimulus. However, the user should note that they will need to source or write software that allows them to define the characteristics of the waveform.
Yes, we have developed GUI control software that allows this to be possible, you can download from this website.
No, after taking advice from collaborators we decided that a ±50mA limit was adequate for most cases, however, it is possible to link two DS5’s together in parallel to increase the overall stimulus output. Please contact us for details.
It is likely that the failure to re-enable the output is accompanied by a warning icon which indicates that re-enabling would result in DC stimulation. If this is the case, then the cause is almost certainly due to (i) a voltage waveform still being applied at the voltage input during the auto-zeroing procedure or (ii) noise being picked up through the input socket. For safety reasons, the DS5 will not re-enable if a significant stimulus current would immediately result.
This socket served two purposes – (i) It allows the operator to upgrade the firmware of the DS5 and (ii) it provides the communication link to control the DS5 settings from PC software. The DS5 User interface software can be downloaded from the Downloads tab on the DS5 product page. Do not connect the DS5 to the PC via the USB cable until this software has been installed.
The DS5 will identify the end point on a stimulation pulse as the stimulus current value falling to within ±400µA for a minimum period of 200µs or a sustained reversal of stimulus polarity (irrespective of the current amplitude). Therefore if you intend to carry out repetitive stimulation pulses of the same polarity, there needs to be a 200µs gap between them. If the pulses are of alternating polarity, there is no requirement for an interval (e.g as in a sine wave).
As with many electronic instruments, certain components within the DS5 make it important that the stimulator is switched ON and “warmed up” for at least an hour before it is used with a subject.
The DS5 is designed for use with human nerves in vivo and as such the sort of currents it generates are in the mA range. Even when the output of the DS5 has been recently autozeroed, some small currents (in the µA range) can persist and while these would be insignificant for human studies, they may be unwelcome in the rodent equivalent. Instead, we would recommend our DS4 stimulator for such non-human research studies.
The DS5 produces two types of audible alert. A high pitched “information” beep serves as confirmation that the operator has toggled or pressed a front panel switch or button. A deeper pitched “warning” tone informs the operator that a safety limit has been reached/exceeded or that intervention is required in response to a warning icon which will be simultaneously displayed on the front panel screen. Audible alerts are switched on by default, but the “information” beep may be disabled by the user via the options menu. When disabled a icon is displayed on the front panel LCD screen. If the DS5 beeps during stimulation, it is likely that there is a problem which the operator should investigate, such as an out of compliance error. The operator should check the LCD display for an information icon, which will explain why the warning is being given.
One of the requirements for our DS5 control software is the Microsoft VC++ 32bit, which is no longer included in new builds of Windows 10. As a result you will need to download and install it prior to installation of our DS5 software. You can obtain it from this link.
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