DS5 Isolated Bipolar Constant Current Stimulator

DS5 Isolated Bipolar Constant Current Stimulator

£7,100.00 exc. VAT

Manufacturer's Net List Price

FEATURES

  • Safety features ensure patient/human subject protection. CE marked medical device
  • Up to ±50mA output from ±120V compliance, in 3 output ranges
  • Isolated constant current output proportional to input “command” voltage
  • Developed for use in QtracW-based nerve excitability testing
  • Compatible with DAQ’s capable of producing an analogue voltage output
SKU: DS5 Categories: , Tag:

Description

DESCRIPTION

The DS5 Isolated Bipolar Constant Current Stimulator allows computer control of stimulus amplitude and timing parameters and has a maximum constant current output of ±50mA. It was originally designed to speed up and enhance human peripheral nerve diagnostics by facilitating semi-automated nerve excitability tests. However, it also has roles in wider aspects of clinical neurophysiology research, including psychological, vestibular system and nociceptive testing.  More recently pairs of DS5’s have been used in research investigating the new technique of temporal interference stimulation (TIS), which may offer a non-invasive, but targeted alternative to deep brain stimulation and other therapies. The DS5 Isolated Bipolar Constant Current Stimulator is a CE marked medical device under the European Medical Device Regulation.

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DOWNLOADS

DS5 Isolated Bipolar Stimulator
Product Information

DS5 Control Software
(installer for Windows)

DS5 Control Software
Installation Guide

DOWNLOAD BROCHURE

Digitimer-Life-Science-Brochure-1

ACCESSORIES

Supplied

  • Mains (Power) lead
  • Operator’s Manual
  • USB Cable

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PUBLICATIONS

J Røikjer, SS Croosu, BF Sejergaard, ... , 2024 , Diagnostic accuracy of perception threshold tracking in the detection of small fiber damage in type 1 diabetes , Journal of Diabetes …
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P Vassiliadis, E Beanato, T Popa, F Windel, ... , 2024 , Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills , Nature Human …
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P Vassiliadis, E Stiennon, F Windel, ... , 2024 , Safety, tolerability and blinding efficiency of non-invasive deep transcranial temporal interference stimulation: first experience from more than 250 sessions , Journal of Neural …
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TN Efthimiou, J Baker, A Clarke, ... , 2024 , Zygomaticus activation through facial neuromuscular electrical stimulation (fNMES) induces happiness perception in ambiguous facial expressions and affects neural … , Social Cognitive and …
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TN Efthimiou, MP Hernandez, A Elsenaar, ... , 2024 , Application of facial neuromuscular electrical stimulation (fNMES) in psychophysiological research: Practical recommendations based on a systematic review … , Behavior research …
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JB Engelmann, M Lebreton, NA Salem-Garcia, ... , 2024 , Anticipatory anxiety and wishful thinking , American Economic …
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HV Cabral, V Devecchi, C Oxendale, ... , 2024 , Effect of movement‐evoked and tonic experimental pain on muscle force production , … Journal of Medicine …
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R Collu, EJ Earley, M Barbaro, M Ortiz-Catalan , 2023 , Non-rectangular neurostimulation waveforms elicit varied sensation quality and perceptive fields on the hand , Scientific Reports
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I Di Pompeo, G D'Aurizio, C Burattini, F Bisegna, ... , 2023 , Positive mood induction to promote well-being and health: A systematic review from real settings to virtual reality. , Journal of …
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M Fabre, L Beullier, C Sutter, ... , 2023 , Cortical facilitation of somatosensory inputs using gravity-related tactile information in humans with vestibular hypofunction , Journal of …
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M Grundei, P Schröder, S Gijsen, ... , 2023 , EEG mismatch responses in a multimodal roving stimulus paradigm provide evidence for probabilistic inference across audition, somatosensation, and vision , Human Brain …
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J Røikjer, SS Croosu, JB Frøkjær, TM Hansen, ... , 2023 , Perception threshold tracking: validating a novel method for assessing function of large and small sensory nerve fibers in diabetic peripheral neuropathy with and … , Pain
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DM Torta, E Meyers, K Polleunis, S De Wolf, ... , 2023 , The effect of observing high or low pain on the development of central sensitization , The Journal of …
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E Meyers, JWS Vlaeyen, ... , 2023 , The effect of high versus low cognitive load on the development of nociceptive hypersensitivity: the roles of sympathetic arousal, sex and pain‐related fear , … Journal of Pain
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DM Sørensen, H Bostock, A Abrahao, A Alaamel, ... , 2023 , Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres , Clinical …
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F Missey, MS Ejneby, I Ngom, MJ Donahue, ... , 2023 , Obstructive sleep apnea improves with non-invasive hypoglossal nerve stimulation using temporal interference , Bioelectronic …
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M D'Agostini, AM Burger, M Franssen, A Perkovic, ... , 2023 , Short bursts of transcutaneous auricular vagus nerve stimulation enhance evoked pupil dilation as a function of stimulation parameters , Cortex
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MJ Wessel, E Beanato, T Popa, F Windel, ... , 2023 , Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning , Nature …
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IR Violante, K Alania, AM Cassarà, E Neufeld, ... , 2023 , Non-invasive temporal interference electrical stimulation of the human hippocampus , Nature …
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FAQs

I have noticed that the DS5 is making a beeping noise when I am delivering stimuli, can I turn this beeping off?
The DS5 produces two types of audible alert. A high pitched information beep serves as confirmation that the operator has toggled or pressed a front panel switch or button. A deeper pitched warning tone informs the operator that a safety limit has been reached/exceeded or that intervention is required in response to a warning icon which will be simultaneously displayed on the front panel screen. Audible alerts are switched on by default, but the information beep may be disabled by the user via the options menu. When disabled a icon is displayed on the front panel LCD screen. If the DS5 beeps during stimulation, it is likely that there is a problem which the operator should investigate, such as an out of compliance error. The operator should check the LCD display for an information icon, which will explain why the warning is being given.
I switched on my DS5 and started using it, but found that the baseline output drifted considerably for the first 30 minutes, even though the voltage input was zero. Why is this?
As with many electronic instruments, certain components within the DS5 make it important that the stimulator is switched ON and warmed up for at least an hour before it is used with a subject.
What is the minimum interval between stimulation pulses using the DS5?
The DS5 will identify the end point on a stimulation pulse as the stimulus current value falling to within ±400µA for a minimum period of 200µs or a sustained reversal of stimulus polarity (irrespective of the current amplitude). Therefore if you intend to carry out repetitive stimulation pulses of the same polarity, there needs to be a 200µs gap between them. If the pulses are of alternating polarity, there is no requirement for an interval (e.g as in a sine wave).
I see there is a USB socket on the back of the DS5, what is this for?
This socket serves two purposes – (i) It allows the operator to upgrade the firmware of the DS5 and (ii) it provides the communication link to control the DS5 settings from PC software. The DS5 User interface software can be downloaded from the Downloads tab on the DS5 product page. Do not connect the DS5 to the PC via the USB cable until this software has been installed.
I see that the DS5 is limited to 50mA, is there the possibility to modify it for a higher output current?
No, after taking advice from collaborators we decided that a ±50mA limit was adequate for most cases, however, it is possible to link two DS5’s together in parallel to increase the overall stimulus output. Please contact us for details.
What is the minimum interval between stimulation “pulses” using the DS5?
The DS5 will identify the end point on a stimulation pulse as the stimulus current value falling to within ±400µA for a minimum period of 200µs or a sustained reversal of stimulus polarity (irrespective of the current amplitude). Therefore if you intend to carry out repetitive stimulation pulses of the same polarity, there needs to be a 200µs gap between them. If the pulses are of alternating polarity, there is no requirement for an interval (e.g as in a sine wave).
I am considering using the DS5 for some studies of rodent nerve excitability. Is the DS5 suitable for this?
The DS5 is designed for use with human nerves in vivo and as such the sort of currents it generates are in the mA range. Even when the output of the DS5 has been recently autozeroed, some small currents (in the µA range) can persist and while these would be insignificant for human studies, they may be unwelcome in the rodent equivalent. Instead, we would recommend our DS4 stimulator for such non-human research studies.
I am currently using the DS5 but have found it difficult to re-enable the output after auto-zeroing and sometimes have to attempt this several times, is there a problem with my stimulator?
It is likely that the failure to re-enable the output is accompanied by a warning icon which indicates that re-enabling would result in DC stimulation. If this is the case, then the cause is almost certainly due to (i) a voltage waveform still being applied at the voltage input during the auto-zeroing procedure or (ii) noise being picked up through the input socket. For safety reasons, the DS5 will not re-enable if a significant stimulus current would immediately result.
Does Digitimer supply a range of electrodes for use with their stimulators?
Digitimer does now offer a range of Neurodiagnostic accessories to be used with our stimulators and amplifiers. We appreciate that we cannot include all types of electrode, so If you experience difficulty obtaining electrodes of the correct specifications, we would be glad to help.
Is it possible to control the settings of the DS5, such as output ranges via remote devices/software?
Yes, we have developed GUI control software that allows this to be possible, you can download from this website.
I cannot find the specification for the current output resolution, can you tell me more about this?
The DS5 behaves like a voltage to current amplifier and is analogue throughout, so it does not have a resolution specification described in these terms. The main limitation to resolution is the noise level in the output signal, as that limits our ability to calibrate the DS5 as the current steps get smaller. However, we have data that confirms the output of the DS5 can be effectively calibrated well below 100uA.
I am interested in purchasing a DS5 stimulator, but I am not sure how I would control it, can you help?
The DS5 has been designed to be as versatile as possible and therefore it should be compatible with most D/A hardware and software. The DS5 merely requires an analogue input of ±1, ±2.5, ±5 or ±10V at the BNC socket on the rear to provide the waveform which describes the stimulus. However, the user should note that they will need to source or write software that allows them to define the characteristics of the waveform.
Are any of your stimulators MRI compatible?
Our stimulators are not classed as MRI safe, as all of them contain ferrous materials which means they cannot be used within a magnetic field. However, as long as they are located beyond the reach of magnetic field or in the scanner control room they may be used. It is important that MRI compatible electrodes and cables are used within the scanner room.
I want to use Axelgaard electrodes with my Digitimer stimulator when stimulating feet in some human research studies, but how should I interface the electrodes with the stimulator?
Axelgaard electrodes are pre-wired with a short pig-tail terminating in a 2mm socket. Digitimer typically uses 1.5mm DIN42802 connectors for our products, so in order to interface these electrodes with a DS7A, DS7AH, DS7R, DS5 or DS8R, you would need one of our D185-HB4 output cables (various lengths) as well as a pair of DS7A-M338 adaptors (30cm or 90cm) which convert from 1.5mm DIN42802 to a 2mm pin.

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