Research and Clinical Instruments Manufacturer & Supplier
Acquisition InterfacesNational Instruments USB-6341-BNCHEKA LIH 8+8 Data Acquisition SystemAmplifiersNeuroLog SystemD360 8-Ch. EP/EEG/EMGD360R 4 Channel Isolated Research Amplifier/FilterD440 2/4 Ch. EMG/EPHEKA EPC10 Patch ClampHEKA EPC10 2/3/4 Ch. Patch ClampHEKA EPC800 Patch ClampAnti-vibration SystemsThorLabs Science DesksNarishige ITS Anti-vibrationNarishige Double MagnetNarishige SBP-2 BaseplateCell InjectorsPLI-100A Pico-injectorPLI-10 Pico-injectorNarishige IM-11-2Narishige IMS-20Narishige IM-21Narishige IM-400Injection Accessories
Incubators & ChambersAutomate Perfusion ChambersMedical Systems MicroincubatorsSSD Brain Slice KeepersSSD Brain Slice ChambersIontophoretic DevicesD380 Dye MarkerMains Noise EliminatorsHumBug Noise EliminatorD400 Mains Noise EliminatorManipulatorsElectrophysiology System ManipulatorsInjection System ManipulatorsStereotaxic Manipulators“YOU” Compact ManipulatorsChronic ManipulatorsAccessoriesMicroscope Adaptors (Ephys)Microscope Adaptors (Injection)
MEA SystemsMED64 – BasicMED64 – Quad IIMED64 – AllegroMED64 – Plex 4/8MED64 – PrestoMED64 – Mobius SoftwareMED64 ProbesPerfusion SystemsStandard & Pressurized PerfusionSmartSquirt Micro-PerfusionIn Vivo Perfusion (Fixation)Heated PerfusionPipette FabricationMicropipette PullersMicroforges & MicrogrindersReplacement PartsCapillary GlassProgrammers & TimersDG2A Train Delay GeneratorNeuroLog System
Signal GeneratorsTG315 Function GeneratorSoftwareQtracW Threshold TrackingAutoMate EasycodeHEKA Chartmaster SoftwareHEKA Patchmaster SoftwareHEKA Fitmaster SoftwareStimulatorsDS2A Constant VoltageDS3 Constant CurrentDS4 Biphasic Constant CurrentDS5 Bipolar Constant CurrentDS7A/DS7AH Constant CurrentDS7R Constant Current ResearchDS8R Biphasic ResearchD121-11 Mounting FrameD185 Transcranial MultiPulseD330 MultiStim SystemNL800A Current Stimulus Isolator
A/D Interface ModulesNL201 – Spike TriggerNL601 – Pulse IntegratorAmplifier ModulesNL100AK – HeadstageNL100RK (NL100AKS & NL100C)NL102G – DC PreamplifierNL104A – AC PreamplifierNL106 – AC/DC AmplifierNL108A – Pressure AmplifierNL109 – Bridge AmplifierNL120S – Audio AmplifierNL820A – 4-Ch. IsolatorNL844 – 4-Ch. AC PreamplifierAnalogue ModulesNL254 – RatemeterNL506 – Analogue SwitchNL703 – EMG Integrator
Digital ModulesNL405 – Width/DelayNL501 – Logic GateNL505 – Flip FlopNL603 – CounterNL730 – Pulse ShiftFilter & Conditioner ModulesNL125/6 – Band-Pass FilterNL134/5/6 – 4-Ch. Low Pass FiltersNL143 – 3-Ch. Difference AmplifierNL144 – 4-Ch. High Pass FilterNL530 – Signal ConditionerNL540 – Inverting Attenuator (Alt. Gain)Generator ModulesNL301 – Pulse GeneratorNL304 – Period GeneratorNL412 – Pulse
NeuroLog AccessoriesAccessory KitsAdaptors & Adaptor CablesSockets (for cable mounting)Sockets (for panel mounting)Plugs (for cable mounting)Extension CablesCablesElectrode HoldersMiscellaneous AccessoriesNeuroLog System CasesNL900D – NeuroLog System CaseNL905 – Compact NeuroLog System Case
Pressure Transducers & AccelerometersPressure TransducersForce TransducersAccelerometersStimulator ModulesNL510 – Pulse BufferNL512 – Biphasic BufferNL800A Constant Current Stimulus Isolator
Application NotesSignal AmplificationTriggering & Pulse GenerationSignal Conditioning Filtering & ProcessingElectrical Stimulation
Isolated Amplifiers for EMG/EEG/EP D440 2/4-Ch. EMG AmplifierD360 8-Ch. Patient Amplifier D360R 4-Ch. Research AmplifierAmplifier Accessories D175 Electrode Impedance Meter D179 Performance Checker D360 Audio Interface D360 USB to Serial Adaptor D177 Bio-Feedback Unit
Peripheral Stimulators DS5 Isolated Bipolar Constant Current Stimulator DS7A & DS7AH HV Constant Current Stimulator DS7R HV Constant Current Research Stimulator DS8R Biphasic Constant Current Stimulator
Transcranial Cortical StimulatorsD185 MultiPulse Cortical Electrical StimulatorStimulator AccessoriesD188 Remote Electrode SelectorElectrode Connection HeadboxesTrigger CablesElectrode HandlesMiscellaneous Items
Neurodiagnostic AccessoriesIntraoperative Neuromonitoring (IONM) Electroecephalography (EEG) Electromyography (EMG)Nerve Conduction Study (NCS) Evoked Potential (EP)Axelgaard Stimulation ElectrodesTouch Proof Plugs Adaptors & Electrode Linkers
Cath SecureCATH-SECURE – OriginalCATH-SECURE – ExtendedCATH-SECURE PlusCATH-SECURE – Dual TabCATH-SECURE For KidsNG SECURE
PessariesPessary Ring Sizing KitsCerclage Pessary (Perforated)Cerclage Pessary (Non Perforated)Ring PessaryThick Ring PessaryCube Pessary (Perforated)Cube Pessary (Non-Perforated)Vaginal DilatorUrethra PessaryBowl PessarySieve Bowl PessaryHodge PessaryClub PessaryTandem Pessary (Perforated)Tandem Pessary (Non-Perforated)
Urodynamic ConsumablesUrodynamics CathetersPump Infusion SetsTransducer Pressure DomesFemale Voiding AdaptorDuckbill ValvesSetguards3-Way Taps
Manufacturer's Net List Price
The DS4 Bi-Phasic Current Stimulator has been developed to meet the needs of life scientists who require a stimulus isolator that can output a bi-phasic isolated constant current stimulus in response to an external command voltage signal, provided by a computer DAC via software. Such a requirement is already met by our NeuroLog System in the form of the NL512 Biphasic Buffer and NL800A Stimulus Isolators, but the DS4 Bi Phasic Stimulator provides our first standalone device to meet this need. The DS4 is intended for use in animal or in vitro electrophysiological applications where low noise is an absolute requirement. The DS4 is not intended for safe human use.
Low Noise Isolated Output Stage
The DS4 features a DC supply to power the control circuitry while the stimulation voltage arises from two banks of batteries in the low noise, optically isolated output stage. The DS4 is not a traditional triggered stimulator, but is instead driven by a biphasic voltage waveform that it converts into a proportional constant current stimulus. This means that the DS4 can produce monophasic or biphasic stimuli which can vary in shape from rectangular pulses to sine waves or even totally arbitrary waveforms. The DS4 features two input sockets – the main INPUT socket is where the voltage command signal is applied and the optional GATE input may be used to turn stimulation on and off using TTL logic, rather like a “soft on/off switch”.
Stimulate with arbitrary shaped waveforms
As the DS4 operates like a voltage to current amplifier, the stimulator has specfic frequency response characteristics, which determine how well it can follow rapidly changing or high frequency command signals. The frequency response plot for the DS4 is shown below, illustrating the performance when a ±5V input is applied with the DS4 set to a maximum input range of ±10V, an output range of ±10mA and a load of 1kohm. The graph shows that the -3dB roll-off is at 50kHz, while the expected DS4 output is constant for frequencies up to 5kHz.
Unique “Inactivity Sensor” Prevents Unwanted DC Stimulation
One of the problems with stimulators that make use of an external voltage source to define a stimulus waveform is that small offsets or noisy baseline signals from the DAC’s used to drive them can result in unwanted battery drain or perhaps worse, low amplitude stimulation. The DS4 uses a special “inactivity sensor” to monitor the input voltage and disable the DS4 output if this voltage falls below 0.15% of the full scale value (in -ve or +ve directions) for a user selectable timeout of 200ms, 500ms, 1s or 2s. Unlike other devices which only ever produce an output when the input voltage exceeds a threshold value, this “inactivity sensor” reduces battery usage and damaging “leak currents” during infrequent stimulation, while at the same time maintaining low levels of zero crossing distortion for repetitive waveforms.
The inactivity sensor timeout can be adjusted between the four possible settings using on board jumpers which are accessible from the battery compartment. It is important to note that the inactivity sensor will result in a slight “glitch” in the stimulus waveform when the DS4 is first used after a period of inactivation. This is because the inactivity sensor prevents any output until the command input voltage exceeds ±0.15% of the full scale.
The DS4 Stimulator uses an external DC power supply to power the input control circuitry and readily available/inexpensive batteries to provide the opto-isolated stimulus voltage source. The DS4 can be fitted into a 19″ rack mounting frame (D121-11) which can hold up to two DS2A’s, DS3’s DS4’s or DG2A’s.
DS4 Bi-Phasic Stimulus Isolator
DS4 Bi-Phasic Stimulus Isolator
DS4 Application Note
Animal/In Vitro Nerve Excitability with QtracW
Publications which cite use of the Digitimer D185 can be found on Google Scholar.
The DS4 operates like a voltage to isolated current amplifier and as such, its behaviour with high frequencies signals can be described in terms of a frequency response. When a ±5V input is applied to a DS4 set to a maximum input range of ±10V, an output range of ±10mA and connected to a load of 1kohm, the -3dB roll-off point is at 50kHz, while the expected DS4 output is constant for frequencies as high as 5kHz.
Yes, the DS4 has featured in a number of studies of evoked neurotransmitter release. Due to it’s ability to be driven by a biphasic voltage waveform, the DS4 can be set up to deliver brief burst of biphasic electrical stimulation via bipolar electrodes, which are precisely timed to occur between the FSCV scans.
The DS5 and DS4 have similar control methods, in that each is driven by a biphasic voltage waveform. For animal use there is no requirement for a medical device and the output current ranges of the DS4 are also more suitable, so we would indeed recommend the DS4 for threshold tracking applications in animals (in vitro or in vivo).
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