Research and Clinical Instruments Manufacturer & Supplier
Acquisition InterfacesNational Instruments USB-6341-BNCHEKA LIH 8+8 Data Acquisition SystemAmplifiersNeuroLog SystemD360 8-Ch. EP/EEG/EMGD360R 4 Channel Isolated Research Amplifier/FilterD440 2/4 Ch. EMG/EPHEKA EPC10 Patch ClampHEKA EPC10 2/3/4 Ch. Patch ClampHEKA EPC800 Patch ClampAnti-vibration SystemsThorLabs Science DesksNarishige ITS Anti-vibrationNarishige Double MagnetNarishige SBP-2 BaseplateCell InjectorsPLI-100A Pico-injectorPLI-10 Pico-injectorNarishige IM-11-2Narishige IMS-20Narishige IM-21Narishige IM-400Injection Accessories
Incubators & ChambersAutomate Perfusion ChambersMedical Systems MicroincubatorsSSD Brain Slice KeepersSSD Brain Slice ChambersIontophoretic DevicesD380 Dye MarkerMains Noise EliminatorsHumBug Noise EliminatorD400 2/4Ch. Mains Noise EliminatorManipulatorsElectrophysiology System ManipulatorsInjection System ManipulatorsStereotaxic Manipulators“YOU” Compact ManipulatorsChronic ManipulatorsAccessoriesMicroscope Adaptors (Ephys)Microscope Adaptors (Injection)
MEA SystemsMED64 – BasicMED64 – Quad IIMED64 – AllegroMED64 – Plex 4/8MED64 – PrestoMED64 – Mobius SoftwareMED64 ProbesPerfusion EquipmentPerfusion SystemsPerfusion AccessoriesPipette FabricationMicropipette PullersMicroforges & MicrogrindersReplacement PartsCapillary GlassProgrammers & TimersDG2A Train Delay GeneratorNeuroLog System
Signal GeneratorsTG315 Function GeneratorSoftwareQtracW Threshold TrackingAutoMate EasycodeHEKA Chartmaster SoftwareHEKA Patchmaster SoftwareHEKA Fitmaster SoftwareStimulatorsDS2A Constant VoltageDS3 Constant CurrentDS4 Biphasic Constant CurrentDS5 Bipolar Constant CurrentDS7A/DS7AH Constant CurrentDS7R Constant Current ResearchDS8R Biphasic ResearchD121-11 Mounting FrameD185 Transcranial MultiPulseD330 MultiStim SystemNL800A Current Stimulus Isolator
A/D Interface ModulesNL201 – Spike TriggerNL601 – Pulse IntegratorAmplifier ModulesNL100AK – HeadstageNL100RK (NL100AKS & NL100C)NL102G – DC PreamplifierNL104A – AC PreamplifierNL106 – AC/DC AmplifierNL108A – Pressure AmplifierNL109 – Bridge AmplifierNL120S – Audio AmplifierNL820A – 4-Ch. IsolatorNL844 – 4-Ch. AC PreamplifierAnalogue ModulesNL254 – RatemeterNL506 – Analogue SwitchNL703 – EMG Integrator
Digital ModulesNL405 – Width/DelayNL501 – Logic GateNL505 – Flip FlopNL603 – CounterNL730 – Pulse ShiftFilter & Conditioner ModulesNL125/6 – Band-Pass FilterNL134/5/6 – 4-Ch. Low Pass FiltersNL143 – 3-Ch. Difference AmplifierNL144 – 4-Ch. High Pass FilterNL530 – Signal ConditionerNL540 – Inverting Attenuator (Alt. Gain)Generator ModulesNL301 – Pulse GeneratorNL304 – Period GeneratorNL412 – Pulse
NeuroLog AccessoriesAccessory KitsAdaptors & Adaptor CablesSockets (for cable mounting)Sockets (for panel mounting)Plugs (for cable mounting)Extension CablesCablesElectrode HoldersMiscellaneous AccessoriesNeuroLog System CasesNL900D – NeuroLog System CaseNL905 – Compact NeuroLog System Case
Pressure Transducers & AccelerometersPressure TransducersForce TransducersAccelerometersStimulator ModulesNL510 – Pulse BufferNL512 – Biphasic BufferNL800A Constant Current Stimulus Isolator
Application NotesSignal AmplificationTriggering & Pulse GenerationSignal Conditioning Filtering & ProcessingElectrical Stimulation
Isolated Amplifiers for EMG/EEG/EP D440 2/4-Ch. EMG AmplifierD360 8-Ch. Patient Amplifier D360R 4-Ch. Research AmplifierAmplifier Accessories D175 Electrode Impedance Meter D179 Performance Checker D360 Audio Interface D360 USB to Serial Adaptor D177 Bio-Feedback Unit
Peripheral Stimulators DS5 Isolated Bipolar Constant Current Stimulator DS7A & DS7AH HV Constant Current Stimulator DS7R HV Constant Current Research Stimulator DS8R Biphasic Constant Current Stimulator
Transcranial Cortical StimulatorsD185 MultiPulse Cortical Electrical StimulatorStimulator AccessoriesD188 Remote Electrode SelectorElectrode Connection HeadboxesTrigger CablesElectrode HandlesMiscellaneous Items
Neurodiagnostic AccessoriesIntraoperative Neuromonitoring (IONM) Electroecephalography (EEG) Electromyography (EMG)Nerve Conduction Study (NCS) Evoked Potential (EP)Axelgaard Stimulation ElectrodesTouch Proof Plugs Adaptors & Electrode Linkers
Cath SecureCATH-SECURE – OriginalCATH-SECURE – ExtendedCATH-SECURE PlusCATH-SECURE – Dual TabCATH-SECURE For KidsNG SECURE
PessariesPessary Ring Sizing KitsCerclage Pessary (Perforated)Cerclage Pessary (Non Perforated)Ring PessaryThick Ring PessaryCube Pessary (Perforated)Cube Pessary (Non-Perforated)Vaginal DilatorUrethra PessaryBowl PessaryUrethra Bowl PessarySieve Bowl PessaryHodge PessaryClub PessaryTandem Pessary (Perforated)Tandem Pessary (Non-Perforated)
Urodynamic ConsumablesUrodynamics CathetersPump Infusion SetsTransducer Pressure DomesFemale Voiding AdaptorDuckbill ValvesSetguards3-Way Taps
The BSC2-2 Dual Channel Interface Chamber equivalent of the BSC2, incorporates two completely independent perfusion lines and channels for incubation of brain slices in interface mode. The base section is identical to the BSC2 and is compatible with the PTC03 Temperature Controller for electrical noise sensitive application, such as electrophysiology. However, the BSC2-2 can also be employed for purely pharmacological studies, where the lower cost PTC04 Temperature Controller is recommended.
This slice recording chamber is a dual version of the BSC2 designed to maintain isolated, living tissues in vitro in ‘interface’ mode and allow stable electrophysiological recordings to be made from the preparation. The temperature is controlled by a low noise proportional control heating unit, the PTC03 or in cases where only incubation or pharmacology is required, with a basic heating unit, the PTC04.
The chamber lower section is similar to the BSC2 for temperature control and oxygenation. Pre-oxygenated medium enters the main body of the chamber through a feed line, one to each well. This fine bore PTFE tube which spirals in the heated distilled water in the lower part of the chamber enters the upper part of the chamber. Here any bubbles in the line break and allow perfusion fluid to flow smoothly towards the slices. Acrylic templates allow the option for use of a single well or can be custom designed. The templates are positioned on the chamber acrylic base and optionally silicone grease is used to make the seal on the bottom (see diagram below).
Typical dead space volume for the single well is approx. 200 ul. The length of PTFE tubing carrying the perfusion solution to the wells has a volume of approx. 400ul. The flow rate of the perfusion fluid is adjusted at the exit well by means of lens tissue which is used to wick solution out of the exit port. By adjusting the over-hang the flow rate is effectively adjusted and determines the characteristics of the meniscus of fluid around the slice preparation. As with all interface preparations, the high oxygen tension is maintained by bubbling a 95% oxygen, 5% carbon dioxide gas mixture through a ceramic bubbler located in the lower heated part of the chamber. This moistened and warmed gas mixture enters the upper part of the chamber via port-holes and is then deflected by an acrylic cover across to the centrally located slice preparation.
The temperature in the upper chamber is maintained by ensuring that the medium and moistened gas mixture enter at the required temperature. This is dependent on the temperature of the lower chamber body which is warmed by a heating element controlled by the Proportional Temperature Controller, PTC03. An optional monitor sensor allows the upper chamber temperature to be checked when required. A more basic version of the controller PTC04 can be used instead where noise control is not an issue as with pre-incubation of slices in interface mode or for pharmacology experiments.
BSC2-2 Dual Channel Interface Chamber
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