The D360 8 Channel Patient Amplifier is a computer-controlled 8-channel patient-isolated AC-coupled biological amplifier and analogue filter system, CE marked according to the European Medical Device Directive and intended for electroencephalography (EEG), electromyography (EMG) and evoked-potential (EP) applications in a research or clinical environment. The D360 features versatile high and low pass filter options as well as a maximum gain of x3,000,000. The system comprises a main amplifier unit, a remote active head-box and dedicated Windows-compatible control software, the latest version of which can be downloaded below.
The Digitimer D360 8-Channel Patient Isolated Amplifier has been referenced in nearly 700 research papers, which can be viewed on Google Scholar. A few of the most highly cited papers published since 2019 are provided below.
Lofredi, R., Tan, H., Neumann, W. J., Yeh, C. H., Schneider, G. H., Kühn, A. A., & Brown, P. (2019). Beta bursts during continuous movements accompany the velocity decrement in Parkinson’s disease patients. Neurobiology of Disease. Elsevier. https://doi.org/10.1016/j.nbd.2019.03.013
Ngo, H. V. V., Seibold, M., Boche, D. C., Mölle, M., & Born, J. (2019). Insights on auditory closed-loop stimulation targeting sleep spindles in slow oscillation up-states. Journal of Neuroscience Methods, 316, 117–124. https://doi.org/10.1016/j.jneumeth.2018.09.006
Lofredi, R., Neumann, W. J., Brücke, C., Huebl, J., Krauss, J. K., Schneider, G. H., & Kühn, A. A. (2019). Pallidal beta bursts in Parkinson’s disease and dystonia. Movement Disorders, 34(3), 420–424. https://doi.org/10.1002/mds.27524
Dupont-Hadwen, J., Bestmann, S., & Stagg, C. J. (2019). Motor training modulates intracortical inhibitory dynamics in motor cortex during movement preparation. Brain Stimulation, 12(2), 300–308. https://doi.org/10.1016/j.brs.2018.11.002
Bologna, M., Guerra, A., Paparella, G., Colella, D., Borrelli, A., Suppa, A., … Berardelli, A. (2019). Transcranial Alternating Current Stimulation Has Frequency-Dependent Effects on Motor Learning in Healthy Humans. Neuroscience, 411, 130–139. https://doi.org/10.1016/j.neuroscience.2019.05.041
Guerra, A., Suppa, A., Asci, F., De Marco, G., D’Onofrio, V., Bologna, M., … Berardelli, A. (2019). LTD-like plasticity of the human primary motor cortex can be reversed by γ-tACS. Brain Stimulation, 12(6), 1490–1499. https://doi.org/10.1016/j.brs.2019.06.029
Ibáñez, J., Hannah, R., Rocchi, L., & Rothwell, J. C. (2020). Premovement Suppression of Corticospinal Excitability may be a Necessary Part of Movement Preparation. Cerebral Cortex, 30(5), 2910–2923. https://doi.org/10.1093/cercor/bhz283
Avanzino, L., Cherif, A., Crisafulli, O., Carbone, F., Zenzeri, J., Morasso, P., … Konczak, J. (2020). Tactile and proprioceptive dysfunction differentiates cervical dystonia with and without tremor. Neurology, 94(6), e639–e650. https://doi.org/10.1212/WNL.0000000000008916
Welniarz, Q., Gallea, C., Lamy, J. C., Méneret, A., Popa, T., Valabregue, R., … Roze, E. (2019). The supplementary motor area modulates interhemispheric interactions during movement preparation. Human Brain Mapping, 40(7), 2125–2142. https://doi.org/10.1002/hbm.24512
Ibáñez, J., Spampinato, D. A., Paraneetharan, V., & Rothwell, J. C. (2020). SICI during changing brain states: Differences in methodology can lead to different conclusions. Brain Stimulation. Elsevier. https://doi.org/10.1016/j.brs.2019.11.002
- Amplifier Main Unit and Preamplifier Headbox
- Mains Lead
- Operator’s Manual
- D360 Client Software (on USB flash drive)
- Daisy-chaining lead for systems comprising multiple D360’s)
- D360 Serial USB Adaptor (D360-USB-TO-SERIAL) – Allows use of USB port when host PC lacks a serial port
- Serial Communication Cable
- Switched Audio Inteface (D360-AIS) – Allows one channel at a time to be audibly monitored via PC sound card.
- Replacement D360 Preamplifier Headbox (D360-HS)
- Electrodes and accessories
1. I am using the D360 Amplifier but I do not have a users manual for it – Is it possible to obtain a copy from Digitimer?
Yes, the users manual is available as a PDF embedded in the D360 Control Software. Just click on “Help” within the menu bar and you can open a copy and save it for future reference.
The latest version of the software can be downloaded from the D360 Software page of this website.
3. I have recently started using a mixture of recording electrode types and now I am having difficulty seeing the resultant EEG activity. It appears as if the amplifier is blocked, as the de-block function momentarily brings the signal back. What is happening?
It is possible that the problem is due to the difference in materials that the electrodes are constructed from. The D360 circuitry is designed for electrodes which are at similar potentials (i.e an input offset different by no more than 100mV). If you use a mixture of electrodes types it is possible that the input offset would exceed 100mV and the amplifier would not be able to compensate for this difference in potential. We would recommend that you determine the potentials the electrodes are at to see if that could be an explanation and consider reverting back to electrodes constructed from the same materials.
4. I want to upgrade to the most recent D360 Control Software, but I am not sure it is compatible with my amplifier, how do I tell?
The most up to date version of the software is available here, however, it must not be used with D360 amplifiers of serial numbers lower than 51, unless they have been specifically modified by Digitimer to accept this version. Please note that the current version of the D360 software is NOT Windows 95 or 98 compatible.
5. I want to use my D360 with a laptop computer, but the computer does not have a serial port, what can I do?
Digitimer have successfully tested and can supply a type of USB to serial port adaptor which allows the D360 to be run via a USB port. However, not all USB to serial port adaptors are compatible, so please contact us further information.
6. I have installed a USB/Serial adaptor supplied by Digitimer, but my computer is failing to communicate with the D360. Can you help?
Typically this problem is due to the USB/serial adaptor not being recognized by Windows or the assigned COM port being to high. Please check within the Device Manager that it is installed correctly and if not, reinstall it using the VCP driver software from the FTDI website. It should also be noted that the Digitimer D360 Control software needed to be installed using an administrator account.
If the installation of the software and adaptor has completed successfully, but the D360 is still not recognised by the computer, check that the COM port assigned to the USB Serial adaptor is lower than 10. COM port values higher than 10 are not visible to the D360. Changes to the COM port assignment can be made within the “USB Serial Adaptor” section of the Windows Device Manager.
7. I have enabled the “D360 signal conditioner” feature in the CED software, but should I also run the D360 Client Software?
The latest versions of CED Spike2 and Signal software packages now have the ability to control the gain and filter settings of the D360 amplifier as well as check the D360 channel impedance values. This means that gain and filter settings are stored alongside the recorded data and changes can be made without having to leave the acquisition software. However, it should be noted that if you run the D360 Client software simultaneously, both it and the CED software will have access to make changes to amplifier settings and this could become confusing. We therefore suggest that Signal and Spike2 users do not run the D360 Client Software and make all changes to D360 settings within the CED software.