Research and Clinical Instruments Manufacturer & Supplier
Acquisition InterfacesNational Instruments USB-6341-BNCHEKA LIH 8+8 Data Acquisition SystemAmplifiersNeuroLog SystemD360 8-Ch. EP/EEG/EMGD360R 4 Channel Isolated Research Amplifier/FilterD440 2/4 Ch. EMG/EPHEKA EPC10 Patch ClampHEKA EPC10 2/3/4 Ch. Patch ClampHEKA EPC800 Patch ClampAnti-vibration SystemsThorLabs Science DesksNarishige ITS Anti-vibrationNarishige Double MagnetNarishige SBP-2 BaseplateCell InjectorsPLI-100A Pico-injectorPLI-10 Pico-injectorNarishige IM-11-2Narishige IMS-20Narishige IM-21Narishige IM-400Injection Accessories
Incubators & ChambersAutomate Perfusion ChambersMedical Systems MicroincubatorsSSD Brain Slice KeepersSSD Brain Slice ChambersIontophoretic DevicesD380 Dye MarkerMains Noise EliminatorsHumBug Noise EliminatorD400 Mains Noise EliminatorManipulatorsElectrophysiology System ManipulatorsInjection System ManipulatorsStereotaxic Manipulators“YOU” Compact ManipulatorsChronic ManipulatorsAccessoriesMicroscope Adaptors (Ephys)Microscope Adaptors (Injection)
MEA SystemsMED64 – BasicMED64 – Quad IIMED64 – AllegroMED64 – Plex 4/8MED64 – PrestoMED64 – Mobius SoftwareMED64 ProbesPerfusion SystemsStandard & Pressurized PerfusionSmartSquirt Micro-PerfusionIn Vivo Perfusion (Fixation)Heated PerfusionPipette FabricationMicropipette PullersMicroforges & MicrogrindersReplacement PartsCapillary GlassProgrammers & TimersDG2A Train Delay GeneratorNeuroLog System
Signal GeneratorsTG315 Function GeneratorSoftwareQtracW Threshold TrackingAutoMate EasycodeHEKA Chartmaster SoftwareHEKA Patchmaster SoftwareHEKA Fitmaster SoftwareStimulatorsDS2A Constant VoltageDS3 Constant CurrentDS4 Biphasic Constant CurrentDS5 Bipolar Constant CurrentDS7A/DS7AH Constant CurrentDS7R Constant Current ResearchDS8R Biphasic ResearchD121-11 Mounting FrameD185 Transcranial MultiPulseD330 MultiStim SystemNL800A Current Stimulus Isolator
A/D Interface ModulesNL201 – Spike TriggerNL601 – Pulse IntegratorAmplifier ModulesNL100AK – HeadstageNL100RK (NL100AKS & NL100C)NL102G – DC PreamplifierNL104A – AC PreamplifierNL106 – AC/DC AmplifierNL108A – Pressure AmplifierNL109 – Bridge AmplifierNL120S – Audio AmplifierNL820A – 4-Ch. IsolatorNL844 – 4-Ch. AC PreamplifierAnalogue ModulesNL254 – RatemeterNL506 – Analogue SwitchNL703 – EMG Integrator
Digital ModulesNL405 – Width/DelayNL501 – Logic GateNL505 – Flip FlopNL603 – CounterNL730 – Pulse ShiftFilter & Conditioner ModulesNL125/6 – Band-Pass FilterNL134/5/6 – 4-Ch. Low Pass FiltersNL143 – 3-Ch. Difference AmplifierNL144 – 4-Ch. High Pass FilterNL530 – Signal ConditionerNL540 – Inverting Attenuator (Alt. Gain)Generator ModulesNL301 – Pulse GeneratorNL304 – Period GeneratorNL412 – Pulse
NeuroLog AccessoriesAccessory KitsAdaptors & Adaptor CablesSockets (for cable mounting)Sockets (for panel mounting)Plugs (for cable mounting)Extension CablesCablesElectrode HoldersMiscellaneous AccessoriesNeuroLog System CasesNL900D – NeuroLog System CaseNL905 – Compact NeuroLog System Case
Pressure Transducers & AccelerometersPressure TransducersForce TransducersAccelerometersStimulator ModulesNL510 – Pulse BufferNL512 – Biphasic BufferNL800A Constant Current Stimulus Isolator
Application NotesSignal AmplificationTriggering & Pulse GenerationSignal Conditioning Filtering & ProcessingElectrical Stimulation
Isolated Amplifiers for EMG/EEG/EP D440 2/4-Ch. EMG AmplifierD360 8-Ch. Patient Amplifier D360R 4-Ch. Research AmplifierAmplifier Accessories D175 Electrode Impedance Meter D179 Performance Checker D360 Audio Interface D360 USB to Serial Adaptor D177 Bio-Feedback Unit
Peripheral Stimulators DS5 Isolated Bipolar Constant Current Stimulator DS7A & DS7AH HV Constant Current Stimulator DS7R HV Constant Current Research Stimulator DS8R Biphasic Constant Current Stimulator
Transcranial Cortical StimulatorsD185 MultiPulse Cortical Electrical StimulatorStimulator AccessoriesD188 Remote Electrode SelectorElectrode Connection HeadboxesTrigger CablesElectrode HandlesMiscellaneous Items
Neurodiagnostic AccessoriesIntraoperative Neuromonitoring (IONM) Electroecephalography (EEG) Electromyography (EMG)Nerve Conduction Study (NCS) Evoked Potential (EP)Axelgaard Stimulation ElectrodesTouch Proof Plugs Adaptors & Electrode Linkers
Cath SecureCATH-SECURE – OriginalCATH-SECURE – ExtendedCATH-SECURE PlusCATH-SECURE – Dual TabCATH-SECURE For KidsNG SECURE
PessariesPessary Ring Sizing KitsCerclage Pessary (Perforated)Cerclage Pessary (Non Perforated)Ring PessaryThick Ring PessaryCube Pessary (Perforated)Cube Pessary (Non-Perforated)Vaginal DilatorUrethra PessaryBowl PessarySieve Bowl PessaryHodge PessaryClub PessaryTandem Pessary (Perforated)Tandem Pessary (Non-Perforated)
Urodynamic ConsumablesUrodynamics CathetersPump Infusion SetsTransducer Pressure DomesFemale Voiding AdaptorDuckbill ValvesSetguards3-Way Taps
Manufacturer's Net List Price
The D360 8 Channel Patient Amplifier is a computer-controlled 8-channel patient-isolated AC-coupled biological amplifier and analogue filter system, CE marked according to the European Medical Device Directive and intended for electroencephalography (EEG), electromyography (EMG) and evoked-potential (EP) applications in a research or clinical environment. The D360 features versatile high and low pass filter options as well as a maximum gain of x3,000,000. The system comprises a main amplifier unit, a remote active head-box and dedicated Windows-compatible control software, the latest version of which can be downloaded below.
Multiple D360 amplifier systems may be connected to a single PC allowing multiples of 8 channels to be controlled by one PC system. Electrode connection is via touch-proof 1.5mm (DIN 42 802) sockets on the headbox and signal output to your chosen acquisition device is possible either through the eight BNC connectors on the front panel or a pair of “D” connectors at the rear of the main unit. Because the Windows compatible D360 Control Software can run in parallel with your data acquisition program, adjustments to the amplifier settings or tasks such as impedance checking and de-blocking can be made while still monitoring data collection.
Among the features included in the D360 are electrode impedance checking and de-block. Impedance checking can be activated from the headstage or control software and impedances levels are indicated in the software or via LEDs conveniently located on the headstage. Thresholds for the impedance levels are fully customisable by the user. The de-block facility can also be accessed via the software or headstage and allows the input circuitry to be stabilised more quickly following electrode placement or movement. D360 Amplifiers now include an external de-block BNC input, which allows the operator to remotely “gate” the de-block function of the amplifier with a TTL-high command. This can be useful for D360 operators who need the amplifier to detect responses with short latency, following a magnetic stimulus pulse. De-blocking while the stimulus is delivered can enhance the recovery time of the amplifier circuitry.
Importantly, the D360 has analogue signal outputs making it compatible with the majority of commercially available data acquisition systems, so users are not restricted to any particular acquisition and analysis software.
D360 8 Channel Isolated Amplifier
D360 Control Software
USB to Serial Adaptor VCP Driver Software
The Digitimer D360 8-Channel Patient Isolated Amplifier has been referenced in nearly 700 research papers, which can be viewed on Google Scholar. A few of the most highly cited papers published since 2019 are provided below.
Lofredi, R., Tan, H., Neumann, W. J., Yeh, C. H., Schneider, G. H., Kühn, A. A., & Brown, P. (2019). Beta bursts during continuous movements accompany the velocity decrement in Parkinson’s disease patients. Neurobiology of Disease. Elsevier. https://doi.org/10.1016/j.nbd.2019.03.013
Ngo, H. V. V., Seibold, M., Boche, D. C., Mölle, M., & Born, J. (2019). Insights on auditory closed-loop stimulation targeting sleep spindles in slow oscillation up-states. Journal of Neuroscience Methods, 316, 117–124. https://doi.org/10.1016/j.jneumeth.2018.09.006
Lofredi, R., Neumann, W. J., Brücke, C., Huebl, J., Krauss, J. K., Schneider, G. H., & Kühn, A. A. (2019). Pallidal beta bursts in Parkinson’s disease and dystonia. Movement Disorders, 34(3), 420–424. https://doi.org/10.1002/mds.27524
Dupont-Hadwen, J., Bestmann, S., & Stagg, C. J. (2019). Motor training modulates intracortical inhibitory dynamics in motor cortex during movement preparation. Brain Stimulation, 12(2), 300–308. https://doi.org/10.1016/j.brs.2018.11.002
Bologna, M., Guerra, A., Paparella, G., Colella, D., Borrelli, A., Suppa, A., … Berardelli, A. (2019). Transcranial Alternating Current Stimulation Has Frequency-Dependent Effects on Motor Learning in Healthy Humans. Neuroscience, 411, 130–139. https://doi.org/10.1016/j.neuroscience.2019.05.041
Guerra, A., Suppa, A., Asci, F., De Marco, G., D’Onofrio, V., Bologna, M., … Berardelli, A. (2019). LTD-like plasticity of the human primary motor cortex can be reversed by γ-tACS. Brain Stimulation, 12(6), 1490–1499. https://doi.org/10.1016/j.brs.2019.06.029
Ibáñez, J., Hannah, R., Rocchi, L., & Rothwell, J. C. (2020). Premovement Suppression of Corticospinal Excitability may be a Necessary Part of Movement Preparation. Cerebral Cortex, 30(5), 2910–2923. https://doi.org/10.1093/cercor/bhz283
Avanzino, L., Cherif, A., Crisafulli, O., Carbone, F., Zenzeri, J., Morasso, P., … Konczak, J. (2020). Tactile and proprioceptive dysfunction differentiates cervical dystonia with and without tremor. Neurology, 94(6), e639–e650. https://doi.org/10.1212/WNL.0000000000008916
Welniarz, Q., Gallea, C., Lamy, J. C., Méneret, A., Popa, T., Valabregue, R., … Roze, E. (2019). The supplementary motor area modulates interhemispheric interactions during movement preparation. Human Brain Mapping, 40(7), 2125–2142. https://doi.org/10.1002/hbm.24512
Ibáñez, J., Spampinato, D. A., Paraneetharan, V., & Rothwell, J. C. (2020). SICI during changing brain states: Differences in methodology can lead to different conclusions. Brain Stimulation. Elsevier. https://doi.org/10.1016/j.brs.2019.11.002
Yes, the users manual is available as a PDF embedded in the D360 Control Software. Just click on “Help” within the menu bar and you can open a copy and save it for future reference.
The latest version of the software can be downloaded from the D360 Software page of this website.
It is possible that the problem is due to the difference in materials that the electrodes are constructed from. The D360 circuitry is designed for electrodes which are at similar potentials (i.e an input offset different by no more than 100mV). If you use a mixture of electrodes types it is possible that the input offset would exceed 100mV and the amplifier would not be able to compensate for this difference in potential. We would recommend that you determine the potentials the electrodes are at to see if that could be an explanation and consider reverting back to electrodes constructed from the same materials.
The most up to date version of the software is available here, however, it must not be used with D360 amplifiers of serial numbers lower than 51, unless they have been specifically modified by Digitimer to accept this version. Please note that the current version of the D360 software is NOT Windows 95 or 98 compatible.
Digitimer have successfully tested and can supply a type of USB to serial port adaptor which allows the D360 to be run via a USB port. However, not all USB to serial port adaptors are compatible, so please contact us further information.
Typically this problem is due to the USB/serial adaptor not being recognized by Windows or the assigned COM port being to high. Please check within the Device Manager that it is installed correctly and if not, reinstall it using the VCP driver software from the FTDI website. It should also be noted that the Digitimer D360 Control software needed to be installed using an administrator account.
If the installation of the software and adaptor has completed successfully, but the D360 is still not recognised by the computer, check that the COM port assigned to the USB Serial adaptor is lower than 10. COM port values higher than 10 are not visible to the D360. Changes to the COM port assignment can be made within the “USB Serial Adaptor” section of the Windows Device Manager.
The latest versions of CED Spike2 and Signal software packages now have the ability to control the gain and filter settings of the D360 amplifier as well as check the D360 channel impedance values. This means that gain and filter settings are stored alongside the recorded data and changes can be made without having to leave the acquisition software. However, it should be noted that if you run the D360 Client software simultaneously, both it and the CED software will have access to make changes to amplifier settings and this could become confusing. We therefore suggest that Signal and Spike2 users do not run the D360 Client Software and make all changes to D360 settings within the CED software.
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