Research and Clinical Instruments Manufacturer & Supplier
Acquisition InterfacesNational Instruments USB-6341-BNCHEKA LIH 8+8 Data Acquisition SystemAmplifiersNeuroLog SystemD360 8-Ch. EP/EEG/EMGD360R 4 Channel Isolated Research Amplifier/FilterD440 2/4 Ch. EMG/EPHEKA EPC10 Patch ClampHEKA EPC10 2/3/4 Ch. Patch ClampHEKA EPC800 Patch ClampAnti-vibration SystemsThorLabs Science DesksNarishige ITS Anti-vibrationNarishige Double MagnetNarishige SBP-2 BaseplateCell InjectorsPLI-100A Pico-injectorPLI-10 Pico-injectorNarishige IM-11-2Narishige IMS-20Narishige IM-21Narishige IM-400Injection Accessories
Incubators & ChambersAutomate Perfusion ChambersMedical Systems MicroincubatorsSSD Brain Slice KeepersSSD Brain Slice ChambersIontophoretic DevicesD380 Dye MarkerMains Noise EliminatorsHumBug Noise EliminatorD400 Mains Noise EliminatorManipulatorsElectrophysiology System ManipulatorsInjection System ManipulatorsStereotaxic Manipulators“YOU” Compact ManipulatorsChronic ManipulatorsAccessoriesMicroscope Adaptors (Ephys)Microscope Adaptors (Injection)
MEA SystemsMED64 – BasicMED64 – Quad IIMED64 – AllegroMED64 – Plex 4/8MED64 – PrestoMED64 – Mobius SoftwareMED64 ProbesPerfusion SystemsStandard & Pressurized PerfusionSmartSquirt Micro-PerfusionIn Vivo Perfusion (Fixation)Heated PerfusionPipette FabricationMicropipette PullersMicroforges & MicrogrindersReplacement PartsCapillary GlassProgrammers & TimersDG2A Train Delay GeneratorNeuroLog System
Signal GeneratorsTG315 Function GeneratorSoftwareQtracW Threshold TrackingAutoMate EasycodeHEKA Chartmaster SoftwareHEKA Patchmaster SoftwareHEKA Fitmaster SoftwareStimulatorsDS2A Constant VoltageDS3 Constant CurrentDS4 Biphasic Constant CurrentDS5 Bipolar Constant CurrentDS7A/DS7AH Constant CurrentDS7R Constant Current ResearchDS8R Biphasic ResearchD121-11 Mounting FrameD185 Transcranial MultiPulseD330 MultiStim SystemNL800A Current Stimulus Isolator
A/D Interface ModulesNL201 – Spike TriggerNL601 – Pulse IntegratorAmplifier ModulesNL100AK – HeadstageNL100RK (NL100AKS & NL100C)NL102G – DC PreamplifierNL104A – AC PreamplifierNL106 – AC/DC AmplifierNL108A – Pressure AmplifierNL109 – Bridge AmplifierNL120S – Audio AmplifierNL820A – 4-Ch. IsolatorNL844 – 4-Ch. AC PreamplifierAnalogue ModulesNL254 – RatemeterNL506 – Analogue SwitchNL703 – EMG Integrator
Digital ModulesNL405 – Width/DelayNL501 – Logic GateNL505 – Flip FlopNL603 – CounterNL730 – Pulse ShiftFilter & Conditioner ModulesNL125/6 – Band-Pass FilterNL134/5/6 – 4-Ch. Low Pass FiltersNL143 – 3-Ch. Difference AmplifierNL144 – 4-Ch. High Pass FilterNL530 – Signal ConditionerNL540 – Inverting Attenuator (Alt. Gain)Generator ModulesNL301 – Pulse GeneratorNL304 – Period GeneratorNL412 – Pulse
NeuroLog AccessoriesAccessory KitsAdaptors & Adaptor CablesSockets (for cable mounting)Sockets (for panel mounting)Plugs (for cable mounting)Extension CablesCablesElectrode HoldersMiscellaneous AccessoriesNeuroLog System CasesNL900D – NeuroLog System CaseNL905 – Compact NeuroLog System Case
Pressure Transducers & AccelerometersPressure TransducersForce TransducersAccelerometersStimulator ModulesNL510 – Pulse BufferNL512 – Biphasic BufferNL800A Constant Current Stimulus Isolator
Application NotesSignal AmplificationTriggering & Pulse GenerationSignal Conditioning Filtering & ProcessingElectrical Stimulation
Isolated Amplifiers for EMG/EEG/EP D440 2/4-Ch. EMG AmplifierD360 8-Ch. Patient Amplifier D360R 4-Ch. Research AmplifierAmplifier Accessories D175 Electrode Impedance Meter D179 Performance Checker D360 Audio Interface D360 USB to Serial Adaptor D177 Bio-Feedback Unit
Peripheral Stimulators DS5 Isolated Bipolar Constant Current Stimulator DS7A & DS7AH HV Constant Current Stimulator DS7R HV Constant Current Research Stimulator DS8R Biphasic Constant Current Stimulator
Transcranial Cortical StimulatorsD185 MultiPulse Cortical Electrical StimulatorStimulator AccessoriesD188 Remote Electrode SelectorElectrode Connection HeadboxesTrigger CablesElectrode HandlesMiscellaneous Items
Neurodiagnostic AccessoriesIntraoperative Neuromonitoring (IONM) Electroecephalography (EEG) Electromyography (EMG)Nerve Conduction Study (NCS) Evoked Potential (EP)Axelgaard Stimulation ElectrodesTouch Proof Plugs Adaptors & Electrode Linkers
Cath SecureCATH-SECURE – OriginalCATH-SECURE – ExtendedCATH-SECURE PlusCATH-SECURE – Dual TabCATH-SECURE For KidsNG SECURE
PessariesPessary Ring Sizing KitsCerclage Pessary (Perforated)Cerclage Pessary (Non Perforated)Ring PessaryThick Ring PessaryCube Pessary (Perforated)Cube Pessary (Non-Perforated)Vaginal DilatorUrethra PessaryBowl PessarySieve Bowl PessaryHodge PessaryClub PessaryTandem Pessary (Perforated)Tandem Pessary (Non-Perforated)
Urodynamic ConsumablesUrodynamics CathetersPump Infusion SetsTransducer Pressure DomesFemale Voiding AdaptorDuckbill ValvesSetguards3-Way Taps
Manufacturer's Net List Price
Stimulate different sites with 1ms switching times
The D188 Remote Electrode Selector allows you to direct an electrical stimulus of up to 1A (at 400V) from a single stimulator to one of up to eight pairs of electrodes. The D188 is supplied with “virtual front panel” software compatible with WindowsTM 7 and higher, which permits manual switching between stimulation sites via a key-press or mouse click. However, the D188 was predominantly designed for situations where stimulation delivery needs to be rapidly switched between sites under remote, digital control. With switching times of 1ms, the D188 Electrode Selector can be used for demanding stimulation applications involving multi-location stimulation in studies of pain, cognitive behaviour or sensory perception. An example of a typical stimulation system incorporating the D188 is given in the diagram below.
Multiple control methods
Precisely timed remote control is possible through the use of TTL compatible digital lines from your data acquisition system. One to one control requires eight digital inputs, however, the D188 Remote Electrode Selector can also operate in a multiplexed mode where only four digital inputs are required. Alternatively, a USB connection to the host computer allows software control of the D188 via a DLL-based API, which can be accessed using your preferred software (C, C++, Visual Basic, C# etc). The D188 is recognized and controllable as a serial device within LINUX operating systems, although our virtual front panel software is not LINUX compatible.
Designed for human research applications
The D188 is silent in operation and the software control panel allows the operator to toggle the LED indicator lights on and off. As a result, the subject of stimulation is not provided with any audible or visual cues of stimulus delivery. The D188 Electrode Selector is not a medical device and use is restricted to human research applications, however, it has been designed to meet certain aspects of IEC 60601-1 relating to safety.
The D188 Remote Electrode Selector not supplied with any stimulator input or electrode connection cables, however, it is possible to purchase additional plugs and cables to suit your requirements. These either allow direct connection of the D188 to our complete range of isolated stimulators. We also offer output extension cables for the D188 in order to increase the distance between the stimulating electrode and the D188 output sockets.
Multiple Stimulator Connection Options
Recommended Connection via D185-HB4 Output Adaptor Cable
For direct connection to a D185-HB4 Output Extension Cable, the D188-09 (200cm) or D188-10 (50cm) 1.5mm cables can be connected between the D188 Electrode Selector and the D185-HB4.
Direct Connection to Digitimer DS5, DS7A/AH or DS8R Stimulator Outputs (4mm)
For direct connection to the stimulator 4mm output sockets, we offer the 50cm long D188-12.
Direct Connection to Digitimer DS2A, DS3 or DS4 Stimulator Outputs (2mm)
For direct connection to the stimulator 2mm output sockets, we offer the 50cm long D188-11.
Electrode Connection Extension Cables
In situations where the electrode lead length is not adequate to connect between the subject and the front panel of the D188, we offer pairs of D188-13 (100cm) or D188-14 (200cm) Output Extension Cables. These cables are fitted with male and female 1.5mm DIN 42802 connectors at each end and are supplied in red and black pairs with sleeving placed at regular intervals to prevent tangling.
D188 Product Datasheet
D188 Accessory Cable Datasheet
D188 Digital Control Schematic
D188 Control Software v3
for Windows x86/x64
Use of the DS5 Bipolar Constant Current Stimulator with the D188 Remote Electrode Selector.
Eftekhar, A., Norton, J. J. S., McDonough, C. M., & Wolpaw, J. R. (2018). Retraining Reflexes: Clinical Translation of Spinal Reflex Operant Conditioning. Neurotherapeutics, 15(3), 669–683. https://doi.org/10.1007/s13311-018-0643-2
Brown, C. A., Scholtes, I., Shenker, N., & Lee, M. C. (2019). Sub-optimal learning of tactile-spatial predictions in patients with complex regional pain syndrome. Pain. https://doi.org/10.1097/j.pain.0000000000001730
Adamczyk, W. M., Manthey, L., Domeier, C., Szikszay, T. M., & Luedtke, K. (n.d.). Spatial summation of pain increases logarithmically 1 2. Biorxiv.Org. https://doi.org/10.1101/2020.06.30.179556
Digitimer only develops for the Windows environment, so unless you are able to run a Windows emulation, we would suggest that you configure the settings of the D188 using a Windows PC. As the settings are persistent, the D188 can then be controlled with digital inputs from a data acquisition interface rather than via the USB connection.
It is important to appreciate that the electrode switching process is not instantaneous. It takes several hundred microseconds for the D188 to switch channels in response to a change in the TTL state of the digital inputs. We recommend that stimulus delivery and digital switching protocols are devised which allow for at least a 1ms pause in stimulation following a digital input state change. If this pause is not adhered to, stimulation may occur in multiple channels during the 1ms transition period.
The D188 accepts standard TTL logic pulses which can be provided by an array of commercially available data acquistion/control hardware. Products from Cambridge Electronic Design, National Instruments, Labjack and many others have all been used to control the D188 for a variety of applications including psychological testing and pain scoring.
In order to use more than one D188 and a single stimulator, it will be necessary for the user to connect the stimulus source, in parallel, to the COM inputs of each D188. In this case, our D185-HB1 output adaptor cable would be a suitable alternative to our D185-HB4. Alternatively, the stimulus source can be connected to a single D188 and one output channel of that unit used to pass the stimulus to a second D188. In this way, multiple D188’s can be “daisy chained” to one stimulator.
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