Topiramate suppresses peri-infarct spreading depolarization and improves outcomes in a rat model of photothrombotic stroke

Author(s): Y Wang, S Yen, YYI Shih, CW Lai, YL Chen, LT Chen…

Year: 2024

Source: iScience

Article URL: https://www.cell.com/iscience/fulltext/S2589-0042(24)01258-6

Abstract:

Ischemic stroke can cause depolarized brain waves, termed peri-infarct depolarization (PID). Here, we evaluated whether topiramate, a neuroprotective drug used to treat epilepsy and …

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