Description
DESCRIPTION
System Overview, Version 8
Signal is a sweep-based data acquisition and analysis package. Uses range from a simple storage oscilloscope to complex applications that require stimulus generation, data capture, control of external devices and custom analysis. This flexibility makes it perfectly suited to a wide range of applications including transient capture, patch and voltage clamp, LTP studies, evoked response and Transcranial Magnetic Stimulation (TMS).
- Signal is simple to set up for data capture and analysis
- Signal has the sampling and analysis features most researchers need, in a user-friendly environment. A built-in script language automates repetitive tasks and provides additional tools for custom analyses and applications.
- Signal includes functions for specific application areas including dynamic clamp, whole cell and patch clamp electrophysiology and evoked response including control of magnetic and other stimulus devices. Signal fully supports control of the Digitimer DS8R constant current stimulator, but can also be used to trigger/control other stimulators within our range.
- Signal can make Resting Motor Threshold (RMT) measurements, using the MTAT 2.0 (PEST) algorithm.
- Signal imports data recorded by many other systems, you can take advantage of this extremely versatile system to analyse existing data.
- Optional windows can show dynamic information in text and images at large scale, to be visible across the lab.
The powerful data capture and time-saving analysis functions of Signal together with one of the CED 1401 family of laboratory interfaces make an extremely flexible and cost effective pillar of any laboratory.
Evoked response and TMS
Output fixed, random and pseudo-random sets of pulses with on- and off-line waveform averaging and measurements of latencies, amplitudes and areas. Signal can control supported transcranial magnetic stimulators during data acquisition, including adjusting stimulator amplitude and timing with checks on stimulator condition. Settings are stored in the corresponding data frame.
LTP and LTD studies
Generate single, paired and trains of pulses on multiple outputs. Automatically measure features including baselines, amplitudes, latencies, areas, durations, percentage rise and decay times, and population spike parameters for single or multiple responses per frame.
Whole cell voltage and current clamp
Interactively control holding potentials and pulse outputs using a graphical pulse editor. Construct I/V plots, leak subtraction and curve fits both on- and off-line.
Dynamic clamp
High speed, fully integrated functions to simulate ion channels and leaks and use simulated synapses to generate hybrid networks.
Single channel patch clamp
Detect single and multi-level channel openings on-line and off-line automatically. Produce measurements such as open/closed times and amplitudes and display result histograms. EMG Record single and multiple channels of EMG with software control of amplifiers such as the CED1902. Perform rectification and smoothing at the touch of a button or under script control. Produce power spectra that update as new data sweeps are captured.
Auditory evoked potentials
Generate complex stimulus protocols and reports under script control. Features include: artefact rejection, digital filtering, generation of sub and grand averages and feature detection using active cursors
System requirements
For sampling, Signal version 8 requires a CED Micro 1401 or Power 1401 intelligent laboratory interface and a PC with Windows 7, 8, 10 or 11, or Intel Macintosh running Windows, and supports 64-bit versions of Windows. The computer must be modern enough to support the SSE2 instruction set. We recommend a minimum of 8GB of RAM. Signal dynamic clamping requires a CED Power1401-3, Power1401 mk II or Micro-4 intelligent laboratory interface.
Both 64-bit and 32-bit OS versions are supplied; either version can be used on systems running a 64-bit OS. When installed on a 64-bit system the 64-bit version provides a performance increase and access to more memory.
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