|
 HEKA
Elektronik are a leading manufacturer of electrophysiology and electrochemistry instrumentation
as well as appropriate acquisition and control software. The current
range of patch clamp amplifiers includes the classic EPC7, the
EPC8, the EPC800 USB and computer controlled EPC10 with USB2.0 connection. The technology
present in the EPC8 has now led to the development of a dedicated
voltammetric amplifier, the EVA8. HEKA also offer a 2 or 3
electrode voltage clamp amplifier for xenopus oocyte recording.
Digitimer also supplies a range of accessories for the HEKA
amplifiers, including pipette holders, o-rings and gold pins -
please contact us for details.
EPC10 USB Patch Clamp Amplifier |
 |
The
flagship of the range, the EPC10 shares many of the features of
its predecessor, the EPC9, but
also possesses many enhancements. The EPC10 is now
integrated with the LIH 8+8 data acquisition interface,
which features a USB2.0 connection. EPC10 amplifier control and
data acquisition is handled by HEKA PatchMaster
software.
Detailed information on software compatibility.
|
|
Major
Features Include:
-
Full computer control
- Automatic self test and calibration
- Automatic compensation of capacitance and Rs
- Integrated with LIH 8+8 acquisition interface featuring
USB2.0 host interface connection
- Ultra-slim headstage design with improved noise
performance
- True current clamp capabilities
- Low frequency voltage clamp
- Digital and telegraphing outputs
-
NEW "Red Star" headstage (also available as
an accessory) features lower noise characteristics
|
EPC10 Double, EPC10 Triple & Quadro USB Patch Clamp Amplifiers |
 |
The
EPC10 double, triple and Quadro are the perfect instruments for
performing patch clamp recordings from up two 4 cells.
Each amplifier is controlled independently through HEKA PatchMaster
software.
Detailed information on software compatibility.
|
|
Major
Features Include:
-
Full computer control
- Automatic self test and calibration
- Automatic compensation of capacitance and Rs
- Integrated with LIH 8+8 acquisition interface(s)
featuring USB2.0 host interface connection
- Complete control of each amplifier and optimized noise
performance
- Holding potential range of +/- 1000 mV
- Digital and telegraphing outputs
|
EPC10
"Plus" Patch Clamp Amplifiers -
No Longer Available |
 |
The EPC 10 PLUS is a fully
computer controlled patch clamp amplifier with a built-in
high-end interface board. Continuing the tradition of
providing the world's best electrophysiology amplifier,
the EPC 10 PLUS has all the features of the EPC 10; but it
goes much further in offering many improvements with
respect to data acquisition capabilities. The EPC 10 PLUS
features the ITC-18 interface, with eight 18-bit AD
converters with a clock rate of 200 kHz (aggregate). The
premium sampling parameters make the EPC 10 PLUS most
suitable for multi-channel and high-resolution recordings.
|
|
Major Features
Include:
- Full
computer control (Mac and Windows based)
- Can be used
with
PatchMaster on Windows operating systems, on MacOS 9
and Mac OS X.
- Automatic
self-test and calibration
Automatic
Capacitance neutralization
- Capacitance
tracking
- Automatic
leak subtraction
- Optimized,
built-in interface
- Integration
with the ITC-18 AD/DA interface to the host computer
- Ultra
slim-line headstage design with improved noise performance
- True Current
Clamp capabilities
- Low
Frequency Voltage Clamp
- Digital
outputs & telegraphing inputs
- Integration
of hardware and software eliminates compatibility problems
on Windows operating systems.
- True noise
measurements from 100 Hz to 15 kHz
- Suitable for
single-channel and whole-cell measurements, loose patch
experiments, capacitance measurements, recordings from
plant cells and organelles, and studying reconstituted
channels in artificial membranes. |
NEW EPC800 USB Patch Clamp Amplifier |
 |
HEKA is proud to introduce a manually controllable patch
clamp amplifier with analog telegraphing outputs for Gain,
Filter Bandwidth, Amplifier Mode and C-Slow. The EPC 800
USB allows third-party acquisition software (e.g. IGOR,
Labview, pCLAMP) to read the status of these amplifier
settings while recording data.
The EPC 800 USB features automatic compensation routines
for Vp-Offset, C-fast and C-slow, includes the low noise
"red star" headstage and offers the a fast true current
clamp circuitry for accurate recording of fast neuronal
action potentials.
|
|
Improvements in comparison
to the EPC 8:
- Telegraphing outputs for
Gain, Bandwidth, Mode & C-Slow
- Automatic Vp-Offset, C-Fast
& C-Slow compensation with the simple push of a button
- Improved current monitor
filters
- USB 2.0 communication for
software control of all amplifier functions
- Low Frequency Voltage Clamp
Mode (LFVC)
- CC+Bridge Mode
- Improved RS Comp Range
|
EPC8 Patch Clamp Amplifier |
 |
The
direct descendent of the EPC7 allows digital control of
gain, mode and filtering. The EPC8 features a
holding potential range of ±500 mV, a low gain range (for
currents up to 2 µA) and a number of other improvements
over the EPC7. This amplifier can be used with the
Instrutech ITC-16, ITC-18 & LIH 8+8 interfaces and HEKA
Software or other hardware/software combinations. Detailed information on
Heka software compatibility.
|
|
Major
Features Include:
-
Manual control using knobs & switches on the front
panel
- Optional digital control of some functions by the
computer
- Holding
potential range of +/-500 mV
- +/-200 mV pipette offset
- A low gain range allows currents
up to 2 µA
- Built-in 'phase tracking'
capabilities
- Variable hardware filters
- C-Slow compensation (0-1000 pF,
calibrated)
|
EPC7
"Plus" Patch Clamp Amplifier |
 |
The
EPC7 represents roughly the seventh in the series of
patch clamp designs in use in the Göttingen laboratories
of Neher and Sakmann since their initial experiments. The
EPC7 is produced by HEKA, the first manufacturer of patch
clamp amplifiers in the world. The EPC7 is the
"classic" patch clamp amplifier and includes all
features necessary to perform patch-clamp experiments of
highest quality. Due to its excellent design the EPC7 is
still manufactured, to this day, with few changes. This amplifier can be used with the
Instrutech ITC-16, ITC-18 & LIH 8+8 interfaces and HEKA
Software or other hardware/software combinations. Detailed information on software compatibility.
|
|
Major
Features Include:
-
Manual control with knobs & switches on the front
panel
- Manual adjustment of the pipette offset (+/- 50 mV)
- Gain: x0.5 to x1000 mV/pA
- Bandwidth: 100 kHz (medium range), 60 kHz (high range)
- Butterworth or Bessel filter
- Manual adjustment of the capacitance compensation
- Noise monitor facilities
- Hardware controlled holding potential with a total range
of +/-200 mV
- Manual adjustment of Rs compensation
|
NEW HEKA iTEV 90
Multi-Electrode Voltage Clamp Amplifier |
 |
HEKA is pleased to release its
first fully computer controlled multi-electrode clamp
amplifier for two/three electrode Xenopus oocyte
recording. The iTEV 90 amplifier is a complete
two-electrode voltage and current clamp amplifier
providing the option to add a third electrode.
|
Major Features
Include:
- Fully computer controlled,
e.g. gain, stimulus filter, filter and clamp gain can be
set from the software.
- Full data integrity; amplifier & acquisition parameters
are stored with the data to allow review & analysis later
- Automated calibration and testing algorithms
- Easy to use software interface provided by PATCHMASTER
- Automated clamp parameter adjustment
- Automated transient compensation
- Slim headstage design
- Dove tail mounting adapter or base plate allow easy
mounting on your manipulator
- Optional 3rd electrode for use as:-
- Extracellular field
compensation electrode
-Additional
intracellular current injection in order to further
increase the clamp speed
|
HEKA EVA8 Voltammetric Amplifier |
 |
The
EVA8 allows exocytotic events such as neurotransmitter
release to be monitored voltammetrically. Besides
high resolution recordings of ion concentration this unit
can be used in studies of quantitative determination of
organic and inorganic compounds, determination of electron
transfer and reaction mechanism, studies of oxidation and
reduction process. This amplifier can be used with the
Instrutech ITC-16 and ITC-18 interfaces as well as the LIH
8+8 and HEKA
Software or other hardware/software combinations. Detailed information on software compatibility.
|
|
Major Features Include:
- Manual or computer controlled
- Capacitance compensation
- Current sensitivity: 5 mV/nA to 1 V/pA
- +/- 2V command ranges
- 17 current output gain ranges
- 7 Pole Bessel Filter adjustable from 0.1 - 30 kHz in 11
steps
- Two external command ranges for 1 V or 2 V at the
headstage.
- Three gain ranges
- Largest measurable currents:
200 pA (50 GOhm, range)
20 nA (500 MOhm, range)
2 µA (5 MOhm, range)
|
|
